Research

Super-charged NK cells for treatment of stem-like/poorly differentiated pancreatic and oral cancers; Journey from basic biology in humanized mice to human clinical trials

We have previously shown that natural killer (NK) cells select and differentiate cancer stem cells (CSCs)/undifferentiated tumors via secreted and membrane bound IFN-gamma (IFN-γ) and TNF-alpha (TNF-α), preventing tumor growth and inducing remodeling of the tumor microenvironment. We report here that tumors resected from either the pancreas or the oral cavity of humanized-BLT (hu-BLT) mice previously implanted with stem-like/undifferentiated pancreatic or oral tumors respectively, and injected with super-charged NK cells exhibited differentiated phenotype, proliferated much less and formed smaller tumors without metastasis. Moreover, the resected tumors exhibited increased surface expression of MHC-class I, CD54 and PD-L1 (B7H1), which were the hallmarks of differentiated tumors previously established in our in vitro studies using NK-differentiated tumors and patient-derived differentiated tumors. In the absence of NK injection, undifferentiated tumors grew faster and remained undifferentiated since they exhibited higher CD44 surface expression in the presence of no increase in MHC class I, CD54 or PDL-1. In addition, unlike their differentiated counterparts, undifferentiated pancreatic or oral tumors remained highly resistant to the chemotherapeutic drugs. Furthermore, we demonstrate that CSCs differentiated with NK cells prior to implantation in hu-BLT mice were unable to grow or metastasize. Indeed, in agreement with our in vitro studies, when NK cell-mediated tumor differentiation was blocked by the addition of antibodies to IFN-γ and TNF-α, tumors grew and metastasized in hu-BLT mice. Similar to cancer patients, pancreatic and oral tumor bearing hu-BLT mice exhibited severe suppression of both NK expansion and function. Suppression of NK cell function not only occurred at the stage of overt cancer, but also at the pre-neoplastic stage. Greater percentages of huCD45+ immune cells infiltrated tumors in NK-injected and AJ2 probiotic bacteria-fed mice, and these tumors exhibited the highest levels of IFN-γ in the presence of decreased IL-6 secretion. Suppressed NK cytotoxicity and/or IFN-γ secretion observed in tumor-bearing mice were restored/increased within all tissue compartments when mice were injected with NK cells, and the highest increases were observed in those which received NK cells and were fed with AJ2. Due to decreased frequencies of NK cells and lower functions of NK cells in hu-BLT mice similar to cancer patients’ NK cells, hu-BLT mice model recapitulate tissue microenvironment in cancer patients and therefore is an appropriate model to study dynamics of tumor growth and progression and immunotherapeutic use of NK cells in cancer therapy. In this presentation, we will also report the current advances in NK cell expansion and therapeutic delivery, and discuss the utility of allogeneic super-charged NK cells in treatment of cancer patients. In addition, we report the preliminary findings from a patient who received super-charged NK cells. Moreover, we discuss the phenotypical and functional differences between the primary and super-charged NK cells. Therefore, due to the indispensable role of NK cells in targeting CSCs/undifferentiated tumors and their role in differentiation of the tumors, NK cells should be placed high in the armamentarium of tumor immunotherapy.

Dr. Jewett

Dr. Jewett is Professor and Director of tumor immunology laboratory at the UCLA School of Dentistry and Medicine. She has published seminal work in tumor immunology and cancer immunotherapy, in particular NK immunotherapy. She holds many key patents, and has given more than 200 invited lectures nationally and internationally and has published greater than 100 research articles and has served on several NIH study section panels. She has trained more than 150 graduate students and health professionals in her laboratory.

Anahid Jewett, Ph.D,MPH
Professor and Director of Tumor Immunology Laboratory
Division of Oral Biology and Medicine
The Jane and Jerry Weintraub Center for Reconstructive Biotechnology
Jonsson Comprehensive Cancer Center
UCLA School of Dentistry and Medicine
Tel: 310-206-3970
Fax: 310-794-7109
Email address: [email protected]
Address: CHS, B3-088
10833 LeConte Ave
Los Angeles, CA. 90095-1668

Affiliation

Dental and Craniofacial Research Institute
Jonsson Comprehensive Cancer Center (JCCC)
The Jane and Jerry Weintraub Center for Reconstructive Biotechnology
UCLA Tumor Immunology subgroup

Websites

David Geffen School of Medicine; http://people.healthsciences.ucla.edu/research/institution/personnel?personnel_id=45339

Jonnson Comprehensive Cancer Center

 https://cancer.ucla.edu/research/find-become-a-member/member-directory?id=129

Frontiers of Tumor Immunity

http://community.frontiersin.org/people/AnahidJewett/116826

Cure Cancer Now Foundation

http://www.curecancernowfoundation.org/

Weintraub center for reconstructive biotechnology

https://weintraubcenter.dentistry.ucla.edu/jewett-lab

Current Laboratory Members

Dr. Kawaljit Kaur- PhD, MS Assistant Project Scientist
Dr. Tahmieh Safaei- DDS, MS Assistant Project Scientist
Dr. Milan Fiala- MD, PhD Assistant Project Scientist
Dr. liu jun, MD, PhD Assistant Project Scientist
Dr. Andre Barkhordarian, PhD Lecturer
Dr. Barbara Breznik PhD Post-doctoral fellow
Emanuela Senjor PhD candidate
Dr. Meng-Wei Ko, DVM PhD candidate
Dr. Po-chun Chen, DVM Masters degree candidate
Dr. Patricia Reese, DDS Masters degree candidate
Dr. Nnishant Chovatiya DDS Masters degree candidate
Dr. Majed bamatraf DDS Masters degree candidate
Dr. Rakshit oberoi DDS Resident in Endodontics
Nelson Poliran, BS, DDS and PhD candidate
kristiyn Y Nguyen. BS, DDS candidate
Paul Wong Undergraduate student
Izabel Comandante Undergraduate student
yuhao wang Undergraduate Student
Matthew Farzam Undergaduate Student
Artin Keshishian Namagerdi Undergaduate Student
Ji Hyuk Seo Undergaduate Student

Ongoing Collaborations Worldwide

NK and High fat Calorie Diet in pancreatic cancer Dr. Guido Eibl, Professor Department of Surgery/David Geffen School of Medicine 
oncolytic viruse and super-charged NK therapy for pancreatic cancer Dr. Yuman Fong, Professor/Chief Department of Surgery/City of Hope
pancreatic cancer and super-charged NK cells Dr. Nicholas Cacalano, Professor Radiation Oncology/David Geffen School of Medicine
CAR/T and NK cells Dr. Prasad  Adusumilli, Professor Surgery/Memorial Sloan-Kettering Cancer Center
Mechanisms of NK cell killing Dr. Janko Kos, Professor Faculty of Pharmacy/University of Ljubljana-Slovenia
Super-charged NK clinical trials Dr. Changge Fang, CSO PAPD/APD/Beijing-China
Omega 3 and NK cells Maria Ohlander Smart-Fish/Norway
AJ2 probiotic in pancreatic cancer Mr. Ming Shin Kou/  Yoshiteru Koide,  Scott Goldsmith, DM Advantage; LA/Probioferm-Iowa
Novel cell killing assay with CTL Elispot Dr. Paul Lehmann, President CTL company/Ohio
NK therapy in melanoma Dr. Andrzej Mackiewicz, Professor Poznan University of Medical Sciences-Poland
NK and targeting of tumors by Abs Drs. Jose Trevejo (Vice President) and Zack Shriver Visterra Co.
NK therapy using activating compounds Nick Kim, Susana Trujillo-Frias Nature Medic
Distribution and marketing bleaching with protectant Tracy Ryan Nkore
Role of NK cells in invasive breast cancer Ira  Skvortsova University of Innsbruk, Austria

Invited Presentations

National Presentations

  1. Anahid Jewett, T. Hoshino, Benjamin Bonavida. Activation of human monocytes tumoricidal activity by OK432 (Abstract #6728 and poster presentation in 1988 FASEB Meeting, Las Vegas, NV).
  2. Anahid Jewett, Nabil Hanna, and Benjamin Bonavida. Lack of correlation of macrophage cell mediated cytotoxicity, secreted TNF-mediated cytotoxicity, and secreted TNF detected by RIA (Abstract and poster presentation. January 22, 1989 TNF meeting, Napa Valley, CA.).
  3. Anahid Jewett and Benjamin Bonavida. TNF and IL-1 gene activation in human monocytes treated with Krestin (PSK). (Abstract and poster presentation in Second International Workshop on Cytokines, Dec., 1989. South Carolina).
  4. Jewett, A.; Nishonian, P.; and Bonavida B. ADCC against HIV-infected cells by monocytes/Macrophages derived from HIV+ and HIV-individuals. Role in the pathogenesis of AIDS (Abstract and poster presentation in 1989 HIV, Lentiviruses and monocyte/macrophage meeting, San Francisco, CA).
  5. Anahid Jewett, B. Bonavida. Antibody dependent cellular cytotoxicity (ADCC) by monocytes from HIV+ and HIV- individuals against HIV-coated target cells. (Abstract and mini symposium oral presentation in 1990 FASEB, New Orleans).
  6. Xiao-Hu Gan, A. Jewett, J. Safrit, H. Morimoto, and B. Bonavida. Macrophage mediated tumor cytotoxicity is upregulated by cisplatinum (CDDP). Abstract 1991, FASEB. Atlanta, Georgia (poster presentation).
  7. Anahid Jewett, Jonathan Katz, Ronald Mitsuyasu, and Benjamin Bonavida. Activation of NK and monocytes from AIDS patients with the BRM OK432. Abstract 1991, oral presentation, FASEB (Atlanta, Georgia).
  8. Laura Lebow, Xiao-Hu Gan, Anahid Jewett, and Benjamin Bonavida. Maturation and differentiation of natural killer (NK) cells: cytokine induction and secretion by Nk subsets. Abstract, FASEB, 1991.
  9. Anahid Jewett, Mark Davis, and Benjamin Bonavida. Maturation and differentiation of sorted non-binder free NK cells derived from human peripheral blood. Abstract, oral presentation, FASEB, Anaheim CA 1992.
  10. Anahid Jewett, Mark Davis, and Benjamin Bonavida. Modulation of several surface antigens on NK cell subpopulations as a function of maturation and differentiation. Abstract and poster presentation. FASEB, Anaheim CA, 1992.
  11. Anahid Jewett and Benjamin Bonavida. Role of endogenous TNF−α secretion in the initiation of IL,2 mediated maturation and differentiation of Free NK cell subset into Killer cells. Abstract and Poster presentation. NK Cell Workshop, St. Petersburg Beach, Florida 1992.
  12. Anahid Jewett and Benjamin Bonavida. Interferon-a has a distinct pathway than Il-2 in the maturation and differentiation of Free NK cell subset into Killer cells. Abstract,Poster and Oral presentation. NK cell Workshop, St. Petersburg Beach, Florida,1992.
  13. Anahid Jewett and Benjamin Bonavida Failure of dissociated NK conjugate to respond to Il-2 or IFN-a mediated activation. Abstract, Poster and Oral presentation. NK cell Workshop, St. Petersburg Beach, Florida 1992
  14. Salahuddin S.Z. Levine S.A. Nakamura S. Kaplan M. Hober D. Jewett A. Xua-Hu G. and B. Bonavida. Cloned tumor cells from AIDs associated lymphoma with interesting in vitro properties. Abstract, American Society of Hematology, Anaheim, CA.1992
  15. Anahid Jewett and Benjamin Bonavida. Cells surface antigens or NK cells are associated with functinal inactivation and activation “Leukocyte Differentiation Antigen Workship” Boston. Poster presentation. November 1993
  16. Anahid Jewett and Benjamin Bonavida. Selective expression of cell surface antigens on subpopulation of peripheral blood-derived NK subsets. “Leukocyte differentiation Antigen Workshop” Boston. Oral presentation. Nov 1993
  17. Demidum A. Salahuddin Z. Lam T. Nakamura S Levine A. Khan R.S. Jewett A. and Bonavida B. Overcoming drug/cytokine resistance f AIDS associated NHL cells following treatment with IFN-g in vitro. AACR. San Francisco
  18. Anahid Jewett and Benjamin Bonavida. Target cell mediated inactivation of human peripheral blood NK cells: Split anergy and programmed cell death in a subset of NK cells. FASEB, Anaheim, California. Poster presentation, April, 1994.
  19. Demidem, A., Bonavida, B., Salahuddin, Z., Lam, T., Nakamura, S., and Jewett, A. Regulation of cell proliferation and sensitization to drugs of human non-hodgkin B lymphoma cell lines by endogenous cytokines. FASEB, Anaheim, California. Poster presentation, April, 1994.
  20. Jewett, A., Giorgi, J., and Bonavida, B. Mechanism of NK inactivation in HIV seropositive individuals. Clinical Immunology meeting, Anaheim, California. Poster presentation, April, 1994.
  21. Anahid Jewett and Benjamin Bonavida. Pivotal roles of TNF receptors expression and endogenous TNF- and IFN-g secretion in the IL-2 mediated activation and differentiation of immature NK cells. Fifth International TNF congress. Asilomar, Monterey, California. Oral presentation, May, 1994.
  22. Bonavida B., Cavalcanti M., and Jewett A. Apoptosis of NK cells. FASEB, Atlanta Georgia, Poster presentation, April 9-13, 1995
  23. Cavalcanti M, Jewett A., X-H Gan, Giorgi J.V. and Bonavida B. Association of phenotypic changes with NK cell inactivation in HIV-infected individuals. FASEB, Atlanta Georgia, Poster presentation, April 9-13, 1995
  24. Jewett A, Cavalcanti M, Bonavida B. Inactivation and programmed cell death of NK cells in ADCC mediated by gp120 coated CD4 target cells and anti-HIV serum.FASEB, Atlanta Georgia, Poster presentation, April 9-13, 1995
  25. Jewett A., Cavalcanti M., and Bonavida B. Involvement of CD16 ( FcRIII) in target cell activation induced apoptosis in NK cells. Oral presentation, FASEB, New Orleans, June 2-6, 1996
  26. Cavalcanti M, Jewett A, and Bonavida B. Failure of IL-2, IL-12, and IL-15 to rescue NK cytolytic function impairment and apoptosis by target cells.FASEB, New Orleans, June 2-6, 1996
  27. Jewett A, Bonavida B. Involvement of the adhesion molecules LFA-1 and ICAM-1 in NK-induced apoptosis. Joint meeting of the American Academy of Allergy, Asthma and Immunology. Journal of Allergy and Clinical Immunology, v.99, n.1, 1997.Oral Presentation.
  28. Mori S, Jewett A, Murakami-Mori K, Cavalcanti M, Bonavida B. The participation of Fas cytotoxic pathway mediated by natural killer cell in tumor cell dependent Fas-mediated cytotoxicity by peripheral blood-derived NK cells. 88 Annual Meeting of the Proceedings of the American Association for Cancer Research Annual Meeting, v.38,304,1997.
  29. Jewett A and Bonavida B. Regulation of anti-CD16 mediated apoptosis in human NK cells by MHC Class I and Killer Inhibitory Receptors(KIR). FASEB, abstract #3512, 1998.
  30. Jewett A and Hume W.R. HEMA and TEGDMA trigger human lymphocyte cytokine secretion in vitro. 27th annual American Association for Dental Research, Minneapolis. March 4-7,1998, oral presentation.
  31. Jewett A, S. Vaziri and W. R. Hume. Oral blood mononuclear cells resist activation- induced cell death in periodontitis patients.Oral presentation, 30th annual American Association for Dental Research (AADR), March 7-10, 2001, Chicago, IL.
  32. A. Jewett, M.Y. Wang and W. R. Hume. Apoptosis-resistant lymphocyte selection is a primary step in 2-hydroxyethylmethacrylate sensitization. Oral presentation, 30th annual American Association for Dental Research (AADR), March 7-10, 2001, Chicago, IL.
  33. Le.D. Wang M,Park N. H. and Jewett A .TRAF3, IgFbp6 and P53 as Potential Therapeutic Targets for Oral Cancers. Oral presentation, 30th annual American Association for Dental Research (AADR), March 7-10, 2001, Chicago, IL.
  34. Jewett A*, Wang M.and Park M. Mechanisms of Resistance of Oral Tumors to Cytotoxic Immune Effectors. Oral presentation, 30th annual American Association for Dental Research (AADR), March 7-10, 2001, Chicago, IL.
  35. ANAHID JEWETT, MEI-YING WANG, MIN SIK PARK. Mechanism of Resistance of Oral Tumors to Matural Killer cell cytotoxicity, Oral presentation, 31th annual American Association for Dental Research (AADR), March, 2002,San Diego, CA.
  36. ANAHID JEWETT, LEONARDO CARLOS FERRER BORDADOR, WYATT R HUME. Gene array analysis of patient lymphocytes treated with 2-hydroxyethylmethacrylate. Oral presentation, 31th annual American Association for Dental Research (AADR), March, 2002,San Diego, CA
  37. ANAHID JEWETT, HIROMI NAKAMURA, MARJAN RUSHEDI, MIN SIK PARK. Iihibition of nuclear NFkB binding in Hep2 cells rescues NK cells from undergoing cell death by tumor cells. Oral presentation, 31th annual American Association for Dental Research (AADR), March, 2002,San Diego, CA
  38. DAVID C. HAN, GEORGE T.-J. HUANG, LOUIS M. LIN, NED WARNER, ANAHID JEWETT, Induced HLA Class II/CD54 cell surface expression and cytokine secretion in oral epithelial cells challenged by selected oral bacteria in vitro, Oral presentation, 31th annual American Association for Dental Research (AADR), March, 2002,San Diego, CA
  39. Tandik Evazyan, and Anahid Jewett. Phenotypic and functional characteristics of lymphocytes derived from oral blood of patients with periodontitis and healthy donors: Lack of activation induced cell death distinguishes oral blood mononuclear cells from peripheral blood mononuclear cells. FASEB, 2004
  40. A. PARANJPE, W. HUME, and A. JEWETT, Susceptibility of human and mouse cells to HEMA mediated apoptotis, 34th annual American Association for Dental Research (AADR), in Baltimore, MD, March, 2005
  41. A. TERUEL, and A. JEWETT, NFkB downmodulation inhibits IL-6 and VEGF secretion in HEp2 tumors, 34th annual American Association for Dental Research (AADR), in Baltimore, MD, March, 2005
  42. M. ROMERO, and A. JEWETT, Lack of TNFa production enhances functional activation of immune effectors, 34th annual American Association for Dental Research (AADR), in Baltimore, MD, March, 2005
  43. A. PARANJPE, W. HUME, and A. JEWETT, Mechanism of HEMA Mediated Apoptosis in Dental Pulp Stromal Cells, 35th annual American Association for Dental Research (AADR), Orlando, Florida, March 8-11, 2006
  44. A. TERUEL and A. JEWETT. Interleukin-6 Secretion Contributes to Immune Inactivation by Oral Tumors. 35th annual American Association for Dental Research (AADR). Orlando, Florida, March 8-11,2006
  45. M. ROMERO, and A. JEWETT. Inhibition of TNF-alpha production enhances immunoreactivity against oral cancers. 35th annual American Association for Dental Research (AADR),Orlando, Florida, March 8-11,2006
  46. A. JEWETT 1, M. ROMERO 2, A. PARANJPE 1, A. TERUEL 2, and N. CACALANO. Targeting NFkB in oral keratinocytes to generate vaccine against periodontal-pathogens. 35th meeting of AADR. March 21-24, 2007 New Orleans, LA, USA. (oral presentation)
  47. N. TSUKIMURA 1, W. YANG 2, N. KOJIMA 1, A. JEWETT 1, and T. OGAWA 1, Co-Culture Effect of Peripheral Blood Mononuclear Cells on Osteoblasts. 36th meeting of AADR. March 21-24, 2007 New Orleans, LA, USA (oral presentation)
  48. A. PARANJPE 1, W. HUME 2, and A. JEWETT. Co-modulation of GAPDH and NFkB in HEMA mediated apoptosis. 36th meeting of AADR March 21-24, 2007 New Orleans, LA, USA (oral presentation)
  49. N. KOJIMA, M. YAMADA, A. PARANJPE, N. TSUKIMURA, K. KUBO, A. JEWETT, and T. OGAWA, Toxicity and Detoxification of Temporary Filling Resin Material. 36th meeting of AADR March 21-24, 2007 New Orleans, LA, USA (oral presentation)
  50. W. YANG, and A. JEWETT. Activation of Smooth Muscle Cells by F. nucleatum during atherogenesis. 36th meeting of AADR. March 21-24, 2007 New Orleans, LA, USA (poster presentation)
  51. Involvement of Fc receptor-mediated NK cell inactivation by oral tumors M. JETHWANI, C. TSAI, C. HEAD, and A. JEWETT. 36th meeting of AADR. March 21-24, 2007 New Orleans, LA, USA (oral presentation)
  52. M. YAMADA 1, N. KOJIMA 1, A. PARANJPE 1, H. AITA 2, W. ATT 1, T. SUZUKI 1, A. JEWETT 1, and T. OGAWA. Cytotoxicity and Detoxification of Poly-methylmethacrylate Resin to Dental Pulp Cells. 36th meeting of AADR. March 21-24, 2007 New Orleans, LA, USA (oral presentation)
  53. Julie Kim, Hong Zhou1, Ana Jewett, and Nicholas A. Cacalano1.Constitutive STAT3 activation in glioblastoma multiforme impairs anti-tumor immunity and production of pro-inflammatory cytokines. AACR, April14-18,2007 (poster presentation).
  54. Avina Paranjpe and Anahid Jewett. N-acetyl Cysteine prevents apoptosis and promotes the differentiation of dental pulp stromal cells. Annual session of AAE, 2008, Vancouver-Canada, April 9-12, (Oral presentation)
  55. Anahid Jewett , “Novel strategies to enhance function, survival and regeneration of pulp” Annual session of AAE, 2008, Vancouver-Canada, April 9-12, keynote lecture
  56. Midori Tachibana and Anahid Jewett. Mechanisms of pulpal infection by pathogenic oral organism Fusobacterium Nucleatum. Annual session of AAE, 2008, Vancouver-Canada, April 9-12, (poster presentation)
  57. Anahid Jewett, “Novel strategies to prevent toxicity of dental materials and enhance function, survival and regeneration of pulp.” Annual Academy of Operative Dentistry meeting in Chicago Feb. 24th, 2009. (key note lecture)
  58. JEWETT, A. PARANJPE2, E.C. SUNG3, and N. CACALANO1, Strategies to induce maximum regeneration of Dental Pulp Stromal Cells, Miami, Florida,
  59. IADR/AADR/CADR 87th General Session and Exhibition (April 1-4,2009) (oral presentation)
  60. H. ARASTEH, N. CACALANO, and A. JEWETT, NK Cells Mediated Lysis Of DPSC’s Is Inhibited By Monocytes, Miami, Florida, IADR/AADR/CADR 87th General Session and Exhibition (April 1-4,2009) (oral presentation)
  61. DADGAR-YEGANEH, M. TACHIBANA, M. ROMERO-REYES, A. PARANJPE, H. ARASTEH, and A. JEWETT, Effects of Fusobacterium Nucleatum on Human Dental Pulp Stromal Cells, Miami, Florida, IADR/AADR/CADR 87th General Session and Exhibition (April 1-4,2009) (oral presentation)
  62. S. SAADAT, N. CACALANO, and A. JEWETT, Monocytes Protect Oral Tumors via NFkB Dependent and Independent Mechanisms, Miami, Florida, IADR/AADR/CADR 87th General Session and Exhibition (April 1-4,2009)(Hutton Competition) (poster presentation)
  63. A. BEHEL1, H. ARASTEH1, W. YANG2, D. FARZAM1, N. CACALANO1, and A. JEWETT1, Potent Cytotoxicity of NK’s against MSC is inhibited by monocytes, , Miami, Florida, IADR/AADR/CADR 87th General Session and Exhibition (April 1-4,2009) (poster presentation)
  64. D. FARZAM1, H.H. TSENG1, K. VU2, A. DADGAR-YEGANEH1, S. SAADAT1, N. CACALANO1, and A. JEWETT1, Monocyte induced oral tumor cell resistance to NK cell cytotoxicity, , Miami, Florida, IADR/AADR/CADR 87th General Session and Exhibition (April 1-4,2009) (poster presentation)
  65. H. GHORBANI-MOGHADDAM, S. SAADAT, D. FARZAM, H.H. TSENG, N. CACALANO, and A. JEWETT, Expression and Function of B7H1 Receptors on Oral Tumors, , Miami, Florida, IADR/AADR/CADR 87th General Session and Exhibition (April 1-4,2009) (poster presentation)
  66. H.C.H. TSENG1, D. FARZAM2, A. ARASTEH3, T. SARDARIAN1, N. CACALANO1, and A. JEWETT1, Monocytes and DCs Elevate Survival and Resistance of Oral Tumors, Washington,DC, AADR Annual Meeting (March 3-6, 2010) (oral presentation)
  67. A. ARASTEH and H.C.H. TSENG, Strategies to Protect DPSCs and Augment Regeneration of Pulpal Tissue, Washington,DC, AADR Annual Meeting (March 3-6, 2010) (poster presentation)
  68. S. KRIFKA1, C. PETZEL1, K. HILLER1, G. SPAGNUOLO2, A. JEWETT3, G. SCHMALZ1, and H. SCHWEIKL1, Resin-monomer modified the expression of antioxidant enzymes, Tampa-Florida, AADR, (March 21-24,2012) (oral presentation)
  69. G.M. ORONA1, H. TSENG2, A. ARASTEH3, and A. JEWETT2, Bacterial Lipopolysaccharides Induce Suppression of Natural Killer Cell Function, Tampa-Florida, AADR, (March 21-24,2012)(oral presentation)
  70. K. KANAYAMA, SIL PARK, H. HELEN TSENG, ANAHID JEWETT, SHUTING SUN, CHARLES E. MCKENNA, ICHIRO NISHIMURA. Different ONJ susceptibility in B6 and Balb/c mice. AADR; March 22, 2014: Charlotte, North Carolina (poster presentation)
  71. P.O. MAUNG, H. TSENG DICK, V.T BUI and A. JEWETT, Combination of chemo-immunotherapy eliminate oral cancer stem cells, AADR/IADR, March 11-14, 2015; Boston, Mass (Oral presentation)
  72. Paytsar Topchyan, Kawaljit Kaur, Anna Kozlowska, , Han-Ching Tseng-Dick, and Anahid Jewett; Super NKs prevent tumor CSC growth in BLT humanized mice; AADR/CADR Annual Meeting (March 16-19, 2016) (Los Angeles)(oral presentation)
  73. Kawaljit Kaur, Keiichi Kanayama,; Ichiro Nishimura and Anahid Jewett; Bisphosphonate mediated immune cell dysfunction in vivo in oral mucosa; AADR/CADR Annual Meeting (March 16-19, 2016) (Los Angeles)(oral presentation)
  74. Diana Wang, Edmund Celis, Avina Paranjpe, Anahid Jewett and Eric Sung; NAC decreases inflammation and pain caused by bleaching agents; AADR/CADR Annual Meeting (March 16-19, 2016) (Los Angeles)(oral presentation)
  75. Yujie Sun , Kawaljit Kaur, William McBride, Anahid Jewett, and Ichiro Nishimura; Therapeutic Activation of MDSC Reduced ONJ Symptoms in Mice; AADR/CADR Annual Meeting (March 16-19, 2016) (Los Angeles)(oral presentation)
  76. Keiichi Kanayama Ph.D, Kawaljit Kaur, Yujie Sun PhD Student, Anahid Jewett, and Ichiro Nishimura; Humanized Mice as Model System for Osteoclast-derived Oral Immune Plasticity; AADR/CADR Annual Meeting (March 16-19, 2016) (Los Angeles)(oral presentation).
  77. Anahid Jewett, Guido Eibl and Kawaljit Kaur. High Fat Diet Risk Factor for Gingival Immunosuppression and Cancer; IADR/AADR; March 22-25; 2017, San Francisco, CA (oral presentation)
  78. Kawaljit Kaur, Yujie Sun, Jessica Cook, Anahid Jewett and Ichiro Nishimura; Mechanisms of Bisphosphonate-mediated Immune Dysfunction in BLT Humanized, IADR/AADR; March 22-25; 2017, San Francisco, CA (poster presentation)
  79. Anahid Jewett; Super-Charged NK Cells For Cancer Treatment; Clinical application of CAR-T cells; Memorial Sloan Kettering Cancer Center (MSKCC), New York. November 16-17; 2017 (oral presentation).
  80. Anahid Jewett; Innate Killer summit 2018; Therapeutic Use of Super-Charged NK Cells Targeting CSCs/Undifferentiated Pancreatic/Oral Tumors in Humanized BLT Mice, and Their Use in Clinical Trials. March 27-29; San Diego, CA (oral presentation).
  81. Meng-Wei Ko, Kawaljit Kuar, Anahid Jewett. Mechanisms of CD8+ T cells Expansion by Super-Charged NK cells; UCLA research day presentations; February 20, 2019, UCLA
  82. Anahid Jewett; Super-charged NK cells and probiotic bacteria for treatment of pancreatic and oral cancers; Journey from in vitro basic biology to studies in humanized mice and human clinical trials; Innate Killer Summit; 19-21 March 2019,| San Diego
  83. Anahid Jewett; Enhanced immunity and increased differentiation of tumor cells within tumor microenvironment by super-charged NK cells; Workshop presentation; Innate Killer Summit; 19-21 March 2019,| San Diego
  84. Anahid Jewett; Day 1 opening; History of NK cells, their advantages and challenges in cancer therapy; Innate Killer Summit; 19-21 March 2019,| San Diego
  85. Anahid Jewett; Day 2 opening; Advantages and challenges of NK therapy within suppressive tumor microenviornment Innate Killer Summit; 19-21 March 2019,| San Diego
  86. Anahid Jewett; Anti-Tumor Effects of Cannabinoids and the Role of the Immune System; past, present and the future; 3rd Annual UCLA Cannabis Research Symposium, May 16th, 2019
  87. Anahid Jewett, Natural Killer Cells, Probiotics, and Cannabis. Cannabis Science Conference west. September 4–6, 2019 Portland, Orgeon
  88. Anahid Jewett, The many key functions of Natural Killers cells in premalignant and malignant stages of tumorigenesis; when these gatekeepers are gone or defective anarchy ensues; The First International Mini Symposium; Successes and Challenges of NK IMMUNOTHERAPY:BREAKING TOLERANCE TO CANCER
  89. RESISTANCE, UCLA, March 20-21, 2020 https://www.1nk-immunotherapyconf.com/
  90. Anahid Jewett, Mechanisms Governing the Selection & Expansion of CD8+ T Cells by Super-Charged NK Cells from Human Donors & Humanized Mice, March 24-26 2020 | San Diego, CA, https://innate-killer.com/whats-on/
  91. Anahid Jewett, Distinct effects of Cannabinoids on Differentiated vs. Cancer Stem cells; Role in Natural Killer Cell activation. March 24-26 2020 | San Diego, CA, https://innate-killer.com/whats-on/
  92. Of 90 presentations 70 were oral presentations. Of the 66 oral presentations 37 was given by A. Jewett and 28 by her Post-doctoral fellows, graduate students (both Master’s and PhD level) and 5 by her collaborators.

International Presentations

  1. Y. Hasegawa, A. Jewett, and B. Bonavida. Monocyte mediated cytotoxicity is Ca++ independent. (Abstract and poster presentation in 7th International Congress of Immunology, Berlin. Aug. 1989).
  2. Anahid Jewett, J. Berliner, B. Bonavida, A. Fogelman, and M. Territo. The effects of modified lipoproteins on monocyte production of tumor necrosis factor (TNF). Abstract presentation in the International Society of Hematology 23rd Congress and the American Society of Hematology 32nd Annual meeting. 1990.
  3. Anahid Jewett, X. Gan, and B. Bonavida. Monocyte mediated activation by PSK and secretion of TNF- and IL-1. Abstract presentation in 3rd International Conference on tumor necrosis factor and related cytokines. Chiba, Japan. November, 1990.
  4.   Benjamin Bonavida, Anahid Jewett, Hideki Morimoto, Colette Broquet, and Pierre Braquet. Aza-alkyl lysolipids block TNF−α secretion by human peripheral blood monocytes/macrophages. Abstract 1991
  5. Benjamin Bonavida, Laura Lebow, and Anahid Jewett. Maturation, differentiation, and functional characterization of purified cytolytic and noncytolytic cell subsets derived from human natural killer cells: new applications in flow cytometry. Abstract 1991. Sweden (NK workshop).
  6. Anahid Jewett, L Lebow, X Gan, and B. Bonavida Induction of IFN-g and TNF−α secretion by purified NK subsets. Abstract 1991, Sweden (NK workshop).
  7. Anahid Jewett and Benjamin Bonavida. Pivotal autocrine/paracrine role of TNF- in the maturation of human peripheral blood “Free” NK cell subset. Abstract, Tumor Necrosis Factor, 1992.
  8. Anahid Jewett and Benjamin Bonavida.  Role of endogenous TNF−α and IFN-g secretion and TNF-R expression on the various pathways of activation of immature NK cells by IL-2, IL-12, and IFN-a.  Oral presentation.  NK cell Workshop, Taurmino, Italy.   May 1994.
  9. Anahid Jewett and Benjamin Bonavida.  Characterization of cell surface receptors associated with target-induced split anergy and programmed cell death in a subset of NK cells.  Oral presentation.  NK cell Workshop, Taurmino, Italy.   May 1994
  10. Anahid Jewett, Pierre Braquet and Benjamin Bonavida.  Inhibition of  TNF- secretion by IL-2 activated human peripheral blood NK cells by a new synthetic dimethyl-podophyllotoxin derivative (BN58705, BDPT).  Poster presentation, Paris, France.
  11. Mori S. Jewett A, Ashkenazi A, Bonavida B. A new cytotoxic factor, APO-2 ligand, is synthesized by natural killer cells and kill target cells by apoptosis. IV th International Workshop of the Society for Natural Immunity, Helsinki, Natural Immunity, v. 15,194, 1997.
  12. Jewett A, Cavalcanti M, Bonavida B. Pivotal role of endogenous TNF−αlpha in the induction of Fas Ligand and apoptosis in a subset of naïve NK cells treated with anti-CD16 antibody. IV th International Workshop of the Society for Natural Immunity, Helsinki, Natural Immunity, v. 15,202, 1997.
  13. Mori S, Jewett A, Murakami-Mori K, Bonavida B. Dexamethason inhibits IL-2 induced TNF−αlpha synthesis and type II TNF receptors (CD120b) expression by NK cells: Possible role of TNF−αlpha in glucocorticoid-mediated NK dysfunction. IV th International Workshop of the Society for Natural Immunity, Helsinki, Natural Immunity, v. 15,202-203, 1997.
  14. Bonavida B, Jewett A, Mori S. Regulation of apoptosis in NK cells. IV th International Workshop of the Society for Natural Immunity, Helsinki, Natural Immunity, v. 15,204, 1997
  15. Jewett A, Berg S, and D.V. Messadi. Mechanism of Natural Killer cell functional inactivation against Oral Cancer. Abstract # 960, IADR, 1998, oral presentation.
  16. Jewett A, Han Y.W. and W. Shi. Regulation of the lymphocyte apoptotic cell death by oral bacteria. Abstract # 2808, 76th general session of International Association of Dental Research (IADR), June, 1998. oral presentation.
  17. Messadi D.V., Jewett A, Le A, Berg S, and CN Bertolami. Role of apoptosis-associated genes in Keloid formation, Abstract #3026, 76th general session of International Association of Dental Research (IADR), June, 1998
  18. A. Jewett, M.Y. Wang and W. R. Hume.  Primary step in HEMA sensitization is selection of a subpopulation of lymphocytes resistant to apoptosis. Oral presentation, 79th general session of International Association of Dental Research (IADR),  june 27-30,2001, Chiba, Japan.
  19. Jewett A. MHC-Class I or CD94 monoclonal antibodies potentiate anti-CD16 antibody mediated cell death in NK cells: possible involvement of TNF-α and NFκB  The seventh annual meeting of the society for Natural Immunity and 19th international natural killer cell workshop, San Juan, Puerto Rico, October 7-9,2002 (poster presentation)
  20. Jewett A*, Wang M.and Park M. Mechanisms of  Resistance  of  Oral  Tumors to Natural Killer cell cytotoxicity. The seventh annual meeting of the society for Natural Immunity and 19th international natural killer cell workshop, San Juan, Puerto Rico, October 7-9,2002 (oral presentation)
  21. ANAHID JEWETT, MEI-YING WANG, MIN SIK PARK.  Mechanism of Resistance of Oral Tumors to Matural Killer cell cytotoxicity, Oral presentation, 80th general session of International Association of Dental Research (IADR), March, 2002,San Diego, CA.
  22.  ANAHID JEWETT, LEONARDO CARLOS FERRER BORDADOR, WYATT R HUME. Gene array analysis of patient lymphocytes treated with 2-hydroxyethylmethacrylate. Oral presentation, 80th general session of International Association of Dental Research (IADR), March, 2002,San Diego, CA
  23. ANAHID JEWETT, HIROMI NAKAMURA, MARJAN RUSHEDI, MIN SIK PARK. Iihibition of nuclear NFkB binding in Hep2 cells rescues NK cells from undergoing cell death by tumor cells. Oral presentation, 80th general session of International Association of Dental Research (IADR), March, 2002,San Diego, CA
  24. DAVID C. HAN, GEORGE T.-J. HUANG, LOUIS M. LIN, NED WARNER, ANAHID JEWETT, Induced HLA Class II/CD54 cell surface expression and cytokine secretion in oral epithelial cells challenged by selected oral bacteria in vitro, Oral presentation, 80th general session of International Association of Dental Research (IADR),March, 2002,San Diego, CA
  25. ANTONIA M. TERUEL, MEERA TEJURA, ANAHID JEWETT. Treatment of Tumor Cells with Non-steroidal Anti-inflammatory Drug Sulindac Increases Survival and Function of Immune Effectors, Oral presentation, 81th general session of International Association of Dental Research (IADR), Gotenborg-Sweden, June 25-28, 2003
  26. NOHELIA CANALES, TALIN EVAZYAN, ANTONIA M. TERUEL, MEERA TEJURA, ANAHID JEWETT, Dendritic Cells (DC) Contribute to Peripheral Blood Lymphocyte Activation When Cultured in the Presence of HEp2 Tumor Cells With No NFkB Activity, Oral presentation, 81th general session of International Association of Dental Research (IADR), Gotenborg-Sweden, June 25-28, 2003
  27. TRI HUYNH, WENYUAN SHI, ANAHID JEWETT, Proteomic Analysis of Cytokines Involved in Apoptosis Induced by F.nucleatum. Oral presentation, 82th general session of International Association of Dental Research (IADR),Hawaii, March 10-13, 2004
  28. AUGUSTINE O FERNANDES, DAVID LE, ANAHID JEWETT, Role of NFkB, JNK and Igfbp6 in oral tumor cell-death. Oral presentation, 82th general session of International Association of Dental Research (IADR),Hawaii, March 10-13, 2004
  29. A. PARANJPE, W. HUME, and A. JEWETT, Susceptibility of human and mouse cells to HEMA mediated apoptotis, 83th general session of International Association of Dental Research (IADR), Baltimore, MD, March 2005 
  30. A. TERUEL, and A. JEWETT, NFkB downmodulation inhibits IL-6 and VEGF secretion in HEp2 tumors, 83th general session of International Association of Dental Research (IADR), Baltimore, MD, March 2005 
  31. M. ROMERO, and A. JEWETT, Lack of TNFa production enhances functional activation of immune effectors, 83th general session of International Association of Dental Research (IADR), Baltimore, MD, March 2005 
  32. A. JEWETT 1, E.C. SUNG 2, and A. PARANJPE, Prevention of composite mediated Toxicity in rat pulp tissue, 84th general session of International Association of Dental Research (IADR), June 28-July 1, 2006, Brisbane, Australia
  33. M. ROMERO, and A. JEWETT. NK cells from TNF-/- mice survive and kill oral tumors , 84th general session of International Association of Dental Research (IADR), June 28-July 1, 2006, Brisbane, Australia
  34. A. PARANJPE, W. HUME, and A. JEWETT, Prevention of HEMA Mediated Apoptosis in Dental Pulp Stromal Cells, 84th general session of International Association of Dental Research (IADR), June 28-July 1, 2006, Brisbane, Australia
  35. A. JEWETT 1, M. ROMERO 2, A. PARANJPE 1, A. TERUEL 2, and N. CACALANO. Targeting NFkB in oral keratinocytes to generate vaccine against periodontal-pathogens. 85th general session of International Association of Dental Research (IADR). March 21-24, 2007  New Orleans, LA, USA. (oral presentation)
  36. N. TSUKIMURA 1, W. YANG 2, N. KOJIMA 1, A. JEWETT 1, and T. OGAWA 1, Co-Culture Effect of Peripheral Blood Mononuclear Cells on Osteoblasts. 85th general session of International Association of Dental Research (IADR). March 21-24, 2007  New Orleans, LA, USA (oral presentation)
  37. A. PARANJPE 1, W. HUME 2, and A. JEWETT. Co-modulation of GAPDH and NFkB in HEMA mediated apoptosis. 85th general session of International Association of Dental Research (IADR). March 21-24, 2007  New Orleans, LA, USA (oral presentation)
  38. N. KOJIMA, M. YAMADA, A. PARANJPE, N. TSUKIMURA, K. KUBO, A. JEWETT, and T. OGAWA, Toxicity and Detoxification of Temporary Filling Resin Material. 85th general session of International Association of Dental Research (IADR). March 21-24, 2007  New Orleans, LA, USA (oral presentation)
  39. W. YANG, and A. JEWETT. Activation of Smooth Muscle Cells by F. nucleatum during atherogenesis. 85th general session of International Association of Dental Research (IADR). March 21-24, 2007  New Orleans, LA, USA (poster presentation)
  40. Involvement of Fc receptor-mediated NK cell inactivation by oral tumors M. JETHWANI, C. TSAI, C. HEAD, and A. JEWETT. 85th general session of International Association of Dental Research (IADR). March 21-24, 2007  New Orleans, LA, USA (oral presentation)
  41. M. YAMADA 1, N. KOJIMA 1, A. PARANJPE 1, H. AITA 2, W. ATT 1, T. SUZUKI 1, A. JEWETT 1, and T. OGAWA. Cytotoxicity and Detoxification of Poly-methylmethacrylate Resin to Dental Pulp Cells. 85th general session of International Association of Dental Research (IADR). March 21-24, 2007  New Orleans, LA, USA (oral presentation)
  42. Wendy Yang and Anahid Jewett. Monocytes induce survival and activation of Mesenchymal Stem Cells. 86th General Session & Exhibition of the IADR, Toronto-Canada, July 2-5, 2008. (oral presentation) 
  43. A. Jewett, A. Paranjpe, E.C. Sung, and W. R. Hume. NAC prevents toxicity without affecting esthetic effect of bleaching. 86th General Session & Exhibition of the IADR, Toronto-Canada, July 2-5, 2008, (oral presentation) 
  44. P. Zarabian, D. Farzam, C. Head, N. Cacalano and A. Jewett. Activation of NFkB in oral tumors by Monocytes-Macrophages. 86th General Session & Exhibition of the IADR, Toronto-Canada, July 2-5, 2008, (oral presentation)
  45. M. Romero-Reyes and A. Jewett. NFkB activation in keratinocytes determines Th1 vs. Th2 type responses. 86th General Session & Exhibition of the IADR, Toronto-Canada, July 2-5, 2008. (oral presentation)
  46. A. Paranjpe, W. R. Hume and A. Jewett. NAC prevents apoptosis through inverse regulation of NFkB and JNK. 86th General Session & Exhibition of the IADR, Toronto-Canada, July 2-5, 2008, (oral presentation)
  47. S. SAADAT1, H.C.H. TSENG2, N. CACALANO2, and A. JEWETT2, NK Cell Survival by DCs Augments Lysis of Oral Tumors, Barcelona, Spain, IADR 88th General Session and Exhibition (July 14-17, 2010) (oral presentation)
  48. A. JEWETT1, H.H.-C. TSENG1, A. ARASTEH2, T. ISHIKAWA1, and H. HERSCHMAN1, Targeted COX2 deletion n monocytes augments NK lysis of tumors, Barcelona, Spain, IADR 88th General Session and Exhibition (July 14-17, 2010) (oral presentation)
  49. G. WALTER, M. JETHWANI, H.H.-C. TSENG, and A. JEWETT, Contrasting Effects of Targeting EGFR on Differentiated and Undifferentiated Tumors, Barcelona, Spain, IADR 88th General Session and Exhibition (July 14-17, 2010) (oral presentation)
  50. H.C.H. TSENG, A. JEWETT, and N. CACALANO, BARRIERS TO SUCCESSFUL EMBRYONIC AND DENTAL PULP STEM CELLS IMPLANTATION, Barcelona, Spain, IADR 88th General Session and Exhibition (July 14-17, 2010) (poster presentation)
  51. A. ARASTEH, and A. JEWETT, STRATEGIES TO PROTECT DPSCS AND AUGMENT REGENERATION OF DENTAL PULP, Barcelona, Spain, IADR 88th General Session and Exhibition (July 14-17, 2010) (poster presentation)
  52. S. SAADAT1, H.C. TSENG2, N. CACALANO2, and A. JEWETT1, Differentiated Oral Tumors Are Resistant to NK Cell Lysis, San Diego, California, 89th IADR General Session and Exhibition (March 16-19, 2011) (oral presentation)
  53. D. CHAUDHARI,, A. PARANJPE, E.C. SUNG and A. JEWETT, NAC Stimulates Differentiation and Protect Composite induced death of DPSCs, San Diego, California, 89th IADR General Session and Exhibition (March 16-19, 2011) (oral presentation)
  54. A. ARASTEH,, N. CACALANO, and A. JEWETT, Strategies to increase survival and differentiation of DPSCs, San Diego, California, 89th IADR General Session and Exhibition (March 16-19, 2011) (poster presentation)
  55. A. JEWETT, A. ARASTEH, and H.-C. TSENG, Blocking NK cytotoxicity by LPS treated COX2 knock out Monocytes, San Diego, California, 89th IADR General Session and Exhibition (March 16-19, 2011) (oral presentation)
  56. C. LANZON, and A. JEWETT, NKs kill Breast, Pancreatic, Lung, Prostate, Oral cancer stem cells, San Diego, California, 89th IADR General Session and Exhibition (March 16-19, 2011) (poster presentation)
  57. H.C. TSENG1, N. CACALANO1, and A. JEWETT2 Monocytes conditioned NK cells support differentiation of oral tumors, San Diego, California, 89th IADR General Session and Exhibition (March 16-19, 2011) (poster presentation)
  58. A. JEWETT, and H. TSENG DICK, Probiotic Bacteria Condition NK cells to Support Cellular Differentiation, IADR, March 20-23, 2013, Seattle-Washington (oral presentation)
  59. H. TSENG DICK, and A. JEWETT, Dual functions of NK in Stem Cell Selection and Differentiation, IADR, March 20-23, 2013, Seattle-Washington (oral presentation)
  60. K. KANAYAMA, S. PARK, H.H. TSENG, A. JEWETT, and I. NISHIMURA, Optimization of ONJ Mouse Model toward Mechanistic Elucidation, IADR, March 20-23, 2013, Seattle-Washington (oral presentation)
  61. V.T. BUI, H.H. TSENG, G. ORONA, and A. JEWETT, Probiotic Bacteria Induce NK(reg) To Mediate Differentiation Of Stem Cells. IADR, June 25-28, 2014, Cape Town, South Africa (Oral Presentation).
  62. H. TSENG DICK1, V. BUI2, and A. JEWETT1, Stem Cell selection and differentiation by Cytotoxic and Regulatory NKs, IADR, June 25-28, 2014, Cape Town, South Africa (Oral Presentation).
  63. P.O. MAUNG1, H. TSENG DICK2, V.T. BUI3, N. CACALANO4, and A. JEWETT2, Combination of chemo and NK immunotherapy eliminate cancer stem cells, IADR, June 25-28, 2014, Cape Town, South Africa (Oral Presentation).
  64. Anahid Jewett, Induction of split anergy in NK cells as master regulator of tumor differentiation, resolution of inflammation and prevention of tumor metastasis. Plenary session speaker; April 27-30, 2015; Ljubljana, Slovenia (oral presentation)
  65. Anna Kozlowska, Natalia Bigott, Paytsar Topchyan, Andrzej Mackiewicz, Anahid Jewett NK cells cytotoxicity in response to melanoma vaccine cells and monitoring of peripheral cytotoxic NK cells activity in surviving patients, (poster presentation) April 27-30, 2015; Ljubljana, Slovenia (oral presentation)
  66. Anahid Jewett, NK Cells Targeting Cancer Stem Cells. Federation of Clinical Immunology Societies, FOCIS. June 24-27, 2015, San Diego, California, symposia keynote speaker; (oral presentation)
  67. Anna Kozlowska1, Natalia Bigott, Paytsar Topchyan, Andrzej Mackiewicz, Anahid Jewett; NK cells cytotoxicity in response to melanoma vaccine cells and monitoring of peripheral cytotoxic NK cells activity in surviving patients; 8th International Conference of Contemporary Oncology:  Integrated Oncology, Genomics, Immunotherapies and Molecular Targets; (16-18 March; 2016) Poznan-Poland; oral presentation
  68. Anahid Jewett; Therapeutic targeting of Cancer Stem Cells by super-charged NK cells; 9th International Conference Of Contemporary Oncology, Genome based precision immuno- and targeted therapy; March 22-24; 2017; Poznan-Poland; oral presentation
  69. Anahid Jewett; NK cell Immunotherapy and Advanced treatment of pancreatic cancer;  8th conference on Experimental and Translational Oncology (CETO); 19-23rd April 2017; Portoros-Ljubljana; chair and oral presentation.
  70. Anahid Jewett; systemic regulation of super-charged NK cell function by intestinal microflora in BLT humanized mice leads to lysis, growth inhibition and balanced differentiation of Cancer Stem Cells; 5th conference of cancer immunotherapy and Immunomonitoring; 24-27th, April 2017, Czech republic-Prague, chair and oral presentation
  71. Anahid Jewett; Super-charged NK cells and probiotic bacteria for treatment of pancreatic and oral cancers; Journey from basic biology in humanized mice to human clinical trialsCancer stem cells, impact on treatment; Seefeld, Tyrol, December 11-15, 2018, Austria
  72. Anahid Jewett, Meng-Wei Ko, Nicholas Cacalano, Changge Fang, Janko Kos and Kawaljit Kaur; Super-charged NK cells for treatment of stem-like/poorly differentiated pancreatic and oral cancers; Journey from basic biology in humanized mice to human clinical trials; Sixth International Conference Cancer Immunotherapy & Immunomonitoring (CITIM); April 29 – May 2, 2019 Tbilisi, Georgia
  73. Anahid Jewett, Therapeutic use of super-charged NK cells targeting CSCs/undifferentiated pancreatic/oral tumors in humanized BLT mice, and their use in clinical trials; Advances in Complex Systems; From Ecology to Economics; Lake Como School of Advanced Studies, Lake Como, Italy. July 22-26; 2019
  74. Keynote speaker, Distinct effects of Cannabinoids on Differentiated vs. Cancer Stem cells; Role in Natural Killer Cell activation, London, June 26-27, 2020
  75. Plenary session speaker, Natural Killers cells in premalignant and malignant stages of tumorigenesis; when these gatekeepers are gone or defective anarchy ensues; FEBS; July 4-8, Ljublana, Slovenia
  76. Plenary session speaker, Natural Killers cells in premalignant and malignant stages of tumorigenesis; when these gatekeepers are gone or defective anarchy ensues;Sept 30-Oct 2, Granada, Spain

Of 76 presentations 69 were oral presentations. Of 69 oral presentations 40was given by A. Jewett and 23 by her post-doctoral fellows and graduate students and 7 by her collaborators. 

Keynote speaker; session chair; organizing committee member and symposium and conference organizer and invited speaker to special conferences;

Symposium organizer: Tumor Immunology/Apoptosis (IADR/AADR/CADR, 81th general session, Gotenborg-Sweden, June 25-28, 2003)

Chairperson: A. JEWETT

Chair’s Opening Remarks

Radioimmunotherapy of head and neck cancer , G. VAN DONGEN, Vrije Universiteit Brussel, Amsterdam, Netherlands

Constitutive Activation of Nuclear Factor-kappaB is a Molecular Switch for the Altered Gene Expression Profile and Malignant Phenotype of Squamous Cell Carcinoma C. VAN WAES, NIDCD/NIH, Bethesda, MD, USA

Mouse Ly49 NK Receptors: Balancing Activation and Inhibition J.R. ORTALDO, National Cancer Institute, Frederick, MD, USA

Targeting NFkB as a strategy for immunotherapy of oral tumors A. JEWETT, UCLA, Los Angeles, CA, USA

Session Chair and discussion leader. International Conference on Maxillofacial Reconstructive Biotechnology. June 19-22, La Bretesche, France, 2005, Oral Presentation. “Prevention of Toxicity to enhance oral health”

Session chair. Periodontal Pathology-Cell Biology. Thursday March 22nd. 85th General Session & Exhibition of the IADR/35th meeting of AADR/31st meeting of CADR. March 21-24, 2007  New Orleans, LA, USA

Key note speaker at Annual meeting of American Association of Endodontics, Vancouver-Canada; Title “Novel strategies to enhance function, survival and regeneration of pulp” April, 2008

Session Chair and discussion leader. International Conference on Maxillofacial Reconstructive Biotechnology . June 21-25, La Bretesche, France, 2007, 1- Session 1- Restorative Materials; Topic of oral presentation “Novel strategies to prevent toxicity of dental materials and enhance function, survival and regeneration of pulp.” 2 -Session 2-Tumorigenesis; Topic of oral presentation “Characterization of specific immune effectors which promote oral cancer, and inactivates the function of Natural Killer cells”

Session Chair, Pulp Biology and Regeneration research, Potential Markers and clinical treatments of the pulp. Saturday July 5th, 86th General Session & Exhibition of the IADR, Toronto-Canada, July 2-5, 2008.

Key note speaker. Annual Academy of Operative Dentistry meeting in Chicago Feb. 24th, 2009. Topic of oral presentation “Novel strategies to prevent toxicity of dental materials and enhance function, survival and regeneration of pulp.”

Lunch and Learning Speaker. IADR/AADR, April 2009. Miami, Florida. Novel strategies to enhance function and survival and regeneration of pulp.

UCLA School of Medicine, Allergy/Immunology seminar, Department of Pediatrics; Sept. 2010; NK cells 

specifically target oral cancer stem cells 

Invited speaker. City of Hope, January 2011, “NK cells specifically target cancer stem cells” 

UCLA School of Dentistry Research Day Faculty presenter, Feb 2011. “Selection and Differentiation of Stem Cells by Natural Killer Cells in infections and Malignancies” 

Invited speaker. UNAM (Mexico City), April 20, 2011,. “Selection and Differentiation of Stem Cells by Natural Killer Cells in infections and Malignancies”

CITIM (2nd International Cancer Immunotherapy and Immunomonitoring conference)- Plenary session speaker, PLENARY SESSION 4 -Improving cancer immunotherapy: New targets, vaccines and models- May2-5, 2011, Budapest-Hungary. “Natural Killer cells preferentially target Cancer Stem Cells; Role of Monocytes in protection against NK cell mediated lysis of Cancer Stem Cells” 

Invited speaker-Thailand, Hat-Yai. Prince of Songkla University, Faculty of Dentistry “Novel strategies to  remove toxicities of dental materials and enhance function, survival and regeneration of the pulp” January, 2012

Invited speaker-Thailand, Hat-Yai. Prince of Songkla University, Faculty of Medicine “Natural Killer Cells Preferentially target Cancer Stem Cells; Role of Monocytes in Protection Against NK Cell Mediated Lysis of Cancer Stem Cells” January, 2012

Invited speaker-Thailand, Hat-Yai. Prince of Songkla University, Faculty of Dentistry and Medicine “Women in Science” January, 2012

Invited speaker-Slovenia, Ljubljana. Jozef Stephan Institute, Faculty of Medicine “Potential rescue, survival and differentiation of cancer stem cells and primary non-transformed stem cells by monocyte-induced split anergy in natural killer cells. March-April, 2012

Invited speaker-Slovenia, Ljubljana. Ljubljana University, Faculty of Pharmacy, “Potentialrole of Cathepsin C in induction of split anergy in NK cells; significance, function and role in differentiation of the stem cells. March-April, 2012

Invited speaker– Key note speaker and opening lecture of 7th Conference on Experimental and translational oncology (CETO), Portoroz-Slovenia, April 2013

Invited speaker- Plenary session speaker and session chair on 3rd Conference on Immunotherapy and Immunomonitoring (CITIM), Krakow-Poland, April 2013 

The 14th international Conference on Functional foods and bioactive compounds was held at UCLA from August 20-22nd , 2013 and was organized by two co-chairs, Dr. Anahid Jewett and Dr. Danik Martirosyan, with the help of 26 other organizing committee members including Dr. Ichiro Nishimura from UCLA School of Dentistry and Dr. Yvette Tache from School of Medicine. Information on the conference program and the members of the organizing committee can be found at the following website; http://functionalfoodscenter.net/Conference_program.html. Drs. Anahid Jewett and Jonathon Braun from UCLA School of Medicine gave the two key note speeches and 33 speakers from different countries gave presentations in 6 sessions chaired by Drs. Anahid Jewett, Garth Nicholson, Robert H. Schiestl, Yvette Tache, Bassem Sheikh, Ichiro Nishimura and Danik Martirosyan. Poster presentations were held on August 22nd and 3 teams of judges determined the winners of poster competition. Abstracts were submitted from 21 countries, including Australia, Canada, Hong Kong, Belarus, Hungaria, India, Indonesia, Italy, Japan, Kenya, Malaysia, Brazil, Poland, Republic of Korea, China, Russia, Saudi Arabia, Taiwan, Thailand, United Kingdom, and United States. The gold medal prize valued at $10,000 was awarded for the best research presentation and 3 poster awards to the three selected research presentations.

Invited keynote speaker, Advanced Course on Immune-based therapies: a coordinated strategy. Faculdade de Medicina da Universidade de Coimbra; Coimbra-Portugal, November 22-30, 2013. 

Topics of presentation 

1-NK cells as effectors of selection and differentiation of stem cells; 

2-Split anergy in NK cells; friend or foe in cancer therapy

Buisness of Science, UCLA Schoolwide venture competition. First place recipient.

Patent to use NAC to prevent Toxicity of tooth bleaching was selected among many at UCLA to compete for funding and marketing by the team of Mariana Fontes, Wenyuan Wang, Bhavaani Jayaram at UCLA business of Science program on Tuesday, May 20, 2014 from 5:00 PM-8:00 PM in Tamkin Auditorium of Ronald Reagan UCLA Medical Center. Our technology received first place with both by Judges vote and popular vote. The title of competition was “NAC Solution Prevents Side-Effects Produced by Teeth Bleaching” The funds will be used to carry out human clinical trials at UCLA School of Dentistry to recruit and assess the effect of NAC in bleaching teeth.

Organizing Committee member and plenary session speaker, for the 4th  Conference on Immunotherapy and Immunomonitoring CITIM, Ljubliana, Slovenia; April 2015.  “Induction of split anergy in NK cells as master regulator of tumor differentiation, resolution of inflammation and prevention of tumor metastasis”. Plenary session 2; April 27-30, 2015; Ljubljana, Slovenia

Invited keynote speaker; Anahid Jewett, Therapeutic targeting of Cancer stem cells by super-charged NK cells;. Sino-US Academic Conference on the clinical application of tumor precision treatment, cutting edge Technology and founding conference of oncology group, division of interventional medicine, Beijing Medical doctor association. (May 5-6th; 2016); PAPD, Beijing-China

UCLA/PAPD collaborative alliance conference (July 7th; 2016)- UCLA

Dr. Anna Kozlowska; NK and vaccine treatment in Melanoma

Dr. Kawaljit Kaur; NK treatment in oral cancer

Dr. Kawaljit Kaur;NK treatment in pancreatic cancer

Paytsar Topchyan; Probiotic treatment for prevention and treatment of oral cancer

Nick Ohanian; NK mediated differentiation of Glioblastomas

Diana Wang; Use of NAC in tooth bleaching and prevention of cancer

Dr. Anna Kozlowska/Jessica Chiang; Tumor differentiation as the means of preventing cancer

Dr. Alison Billroth-MacLurg; Methods to purify NK cells

Dr. Kawaljit Kaur; Obesity, Kras mutation, NK suppression and pancreatic cancer

Dr. Anahid Jewett; Mechanism of NK cell suppression in cancer

Dr. Anahid Jewett/Nick Ohanian; Future strategies to optimize NK therapy in cancer

Invited keynote speaker; International conference on New approaches fighting Cancer and againg; Nanjing-China; Title “Novel immunetherapeutics for cancer”; December 2-4; 2016

Leo and Ann Pancreatic cancer Trial Symposium; January 18th, 2017; San Francisco; organized by City of Hope

Selected one of the five labs to receive funding through Pancreatic cancer project raising $300 million dollars for pancreatic cancer research in USA; Meeting and discussion of the selected labs. January 19th, 2017; Four seasons Hotel, San Francisco.

Team meeting of UCLA and City of Hope; Thursday September 15th, 2016; City of Hope; Tuesday February 14th; UCLA; Discussion and lecture presentations of Oncolytic viruses and NK Immunotherapy.

Team monthly meeting of pancreatic group at UCLA; January 17th, February 14th, 2017. Discussion and lecture presentation of pancreatic cancer working group

Invited speaker; 9th International Conference Of Contemporary Oncology, Genome based precision immuno- and targeted therapy; March 22-24; 2017; Poznan-Poland; Title, “Therapeutic targeting of Cancer Stem Cells by super-charged NK cells”

Invited spearker and lecturer; University of Ljubljana; faculty of Pharmacy; 10-14 April 2017; Ljubljana-Slovenia

Invited speaker and lecturer; Kranskagora; Pharmacy students and faculty general meeting; April 16-18; Ljubljana-Slovenia

Invited speaker and chair; 8th conference on Experimental and Translational Oncology (CETO); 19-23rd April 2017; Portoros-Slovenia. Title “NK cell Immunotherapy and Advanced treatment of pancreatic cancer”.

Invited speaker and Chair; 5th conference of cancer immunotherapy and Immunomonitoring; 24-27th, Czech republic-Prague, Title “Systemic regulation of super-charged NK cell function by intestinal microflora in BLT humanized mice leads to lysis, growth inhibition and balanced differentiation of Cancer Stem Cells”

Invited key note speaker; “Cancer Stem Cells; Imapact on Treatment”; Dec 2018; Obergurgl, Tyrol, Austria

Invited speaker; Clinical application of CAR-T cells; Memorial Sloan Kettering Cancer Center (MSKCC), New York. November 16-17; 2017.

Invited speaker; Innate Killer summit 2018; Therapeutic Use of Super-Charged NK Cells Targeting CSCs/

Undifferentiated Pancreatic/Oral Tumors in Humanized BLT Mice, and Their Use in Clinical Trials. March 27-29; San Diego, CA.

Invited speaker; Research Advisory Committee; UCLA School of Dentistry; February 5th, 2018.

Invited speaker; Cancer stem cells, impact on treatment; Seefeld, Tyrol, December 11-15, Austria

Invited speaker and Chair of conference. Innate Killer Summit; 19-21 March 2019 | San Diego

Organizing and Scientific committee member and plenary session chair and speaker; Sixth International Conference Cancer Immunotherapy & Immunomonitoring (CITIM); April 29 – May 2, 2019 Tbilisi, Georgia

Invited speaker; Advances in Complex Systems; From Ecology to Economics; Lake Como School of Advanced Studies, Lake Como, Italy. July 22-26; 2019

Keynote speaker; Natural Killer Cells, Probiotics, and Cannabis. Cannabis Science Conference west. September 4–6, 2019 Portland, Orgeon

Organizer and plenary speaker; The many key functions of Natural Killers cells in premalignant and malignant stages of tumorigenesis; when these gatekeepers are gone or defective anarchy ensues; The First International Mini Symposium; Successes and Challenges of NK IMMUNOTHERAPY:

​BREAKING TOLERANCE TO CANCER RESISTANCE,  UCLA, March 20-21, 2020 https://www.1nk-immunotherapyconf.com/

Chair and plenary speaker, Mechanisms Governing the Selection & Expansion of CD8+ T Cells by Super-Charged NK Cells from Human Donors & Humanized Mice and Distinct effects of Cannabinoids on Differentiated vs. Cancer Stem cells; Role in Natural Killer Cell activation. March 24-26 2020 | San Diego, CA, https://innate-killer.com/whats-on/

Keynote speaker, Distinct effects of Cannabinoids on Differentiated vs. Cancer Stem cells; Role in Natural Killer Cell activation, London, June 26-27, 2020

Plenary session speaker, Natural Killers cells in premalignant and malignant stages of tumorigenesis; when these gatekeepers are gone or defective anarchy ensues; FEBS; July 4-8, Ljublana, Slovenia

Plenary session speaker, Natural Killers cells in premalignant and malignant stages of tumorigenesis; when these gatekeepers are gone or defective anarchy ensues;Sept 30-Oct 2, Granada, Spain

Other Invited Lectures

  1. Annual HHMI presentations for high school students (2009-present)
  2. Weintraub Center seminar presentations (2002-present) 
  3. Student Research Group/ School of Dentistry, 2007
  4. UCLA Gene Medicine Seminar 2003
  5. UCLA Bioengineering symposium 2002
  6. UCLA Gene Medicine Seminar 2001
  7. UCLA Dental Research Institute Seminar Series, 1998,1999,2002,2003
  8. USC Infection and Immunity group seminar series 2000
  9. Medical College of Virginia (MCV),  Phillips Institute and Cancer Center Seminar series 2000
  10. University of Pacific, School of Pharmacy 2000 

Publications in chronological order

  1. Wright, S.C., Jewett, A., Mitsuyasu, R., and Bonavida, B.  Spontaneous cytotoxicity and TNF production by peripheral blood monocytes from AIDS patients.  J. Immunol.  141: 99-104, 1988.
  2. Bonavida, B. and Jewett, A.  Activation of human peripheral blood derived monocytes by OK432  (Streptococcus pyogenes).  Augmented cytotoxicity and secretion of TNF and synergy with rIFN-.  Cell. Immunol.  123:373-383, 1989.
  3. Bonavida, B., Jewett, A., and Mencia-Huerta, J.M.  Biology of Platelet Activating Factor (PAF) Interaction with Human Peripheral Blood Monocytes and induction of Tumor Necrosis Factor (TNF) Secretion. In   “The Ginkgolides Vol 2”, Chemistry, Biology, Pharmacology and Clinical Perspectives, P. Braquet, ed., J. R. Proc. science Publishers, 2:685-696, 1989.
  4. Jewett, A. and Bonavida, B.  Peripheral blood monocytes derived from HIV+ individuals mediate antibody dependent cellular cytotoxicity. Clin. Immunol. Immunopath.  54:192-199, 1990.
  5. Jewett, A., Giorgi, J.V., and Bonavida, B.  Antibody dependent cellular cytotoxicity (ADCC) against HIV-coated target cells by peripheral blood monocytes from HIV seropositive asymptomatic patients.  J. Immunol. 145:4065-4071, 1990.
  6. Gan, X.-H., Jewett, A., and Bonavida, B.  Activation of human peripheral blood derived monocytes by CDDP:  Enhanced tumoricidal activity and secretion of TNF-.  Nat. Imm. Cell Growth Reg. 11:144-155, 1992.
  7. Lebow, L.T., Gan, X.-H., Jewett, A., and Bonavida, B. Induction and secretion of TNF- during the maturation and differentiation of human natural killer cells.  In “Tumor necrosis factor:  Structure function relationship and clinical application,” T. Osawa and B. Bonavida, eds., Karger Press, Basel, pp. 144-151, 1992.
  8. Lebow, L.T., Jewett, A., and Bonavida, B.  Killer cell recruitment and renewal capacity of purified cytolytic and non-cytolytic human peripheral blood natural killer cell subsets.  J. Immunol. 150:320-329, 1993.
  9. Bonavida, B., Lebow, J.T., and Jewett, A.  Natural Killer cell subsets: Maturation, differentiation and regulation.  Nat. Immunity 12:194-208, 1993.
  10. Jewett, A. and Bonavida, B.  Pivotal role of endogenous TNF- in the IL-2 driven activation and proliferation of the functionally immature NK Free subset.  Cell. Immunol. 151, 257-269, 1993.
  11. Bonavida, B., Braquet, M., Lebow, L.T., and Jewett, A.  Qualitative and quantitative analysis of subpopulations of cytotoxic effector cells by flow cytometry.  J. Lipid Mediators.  9:19-25, 1994.
  12. Jewett, A. and Bonavida, B.  Activation of the human immature natural killer subset by IL-12 and its regulation by endogenous TNF- and IFN- secretion.  Cell. Immunol. 154:273-286, 1994.
  13. Jewett, A. and Bonavida, B.  Pentoxfylline suppresses  IL-2 mediated activation of immature human natural killer cells by inhibiting endogenous TNF- secretion.  J. Clin. Immunol.   14(1):31-38, 1994.
  14. Bonavida, B. and Jewett, A.  Maturation, differentiation, and inactivation of human peripheral blood NK cells.  In “L’Immuno-Intervention”, S. Chouaib and J.M. Mencia-Huerta, eds., Media Science, pp. 181-188, 1994.
  15. Hober, D., Jewett, A., and Bonavida, B.  Lysis of uninfected HIV-gp120 coated peripheral blood derived T lymphocytes by monocyte-mediated antibody dependent cellular cytotoxicity.  FEMS Immunol. & Med. Microbiol. 10:83-92, 1995.
  16. Jewett, A. and Bonavida, B.  Target-induced anergy of Natural Killer cytotoxic function is restricted to the NK-target conjugate subset.  Cell. Immunol.  160:91-97, 1995.
  17. Jewett, A. and Bonavida, B.  Interferon- activates cytotoxic function but inhibits interleukin-2 mediated proliferation and tumor necrosis factor- secretion of immature human natural killer cells.  J. Clin. Immunol.  15:35-44, 1995.
  18. Hu, P.F., Hultin, L.E., Hultin, P., Hausner, M.A., Hirji, K., Jewett, A., Bonavida, B., Detels, R., and Giorgi, J.V.  Natural killer cell immunodeficiency in HIV disease is manifest by profoundly decreased number of CD16+CD56+ cells and expansion of a population of CD16dimCD56– cells with low lytic activity.  J. Acquired Immune Deficiency Syndromes and Human Retrovirology  10:331-340, 1995.
  19. Jewett, A. and Bonavida, B.  Target-induced split anergy and apoptosis in a subset of human natural killer cells.  J. Immunol. 156:907-915, 1996.
  20. Jewett, A., Gan, X.H., Lebow, L., and Bonavida, B.  Differential secretion of TNF- and IFN-g by human peripheral blood-derived NK subsets and association with functional maturation.  J. Clin. Immunol.  16:46-54,1996.
  21. Stewart, S.A., Fruer, G., Jewett, A., Lee, F.V., Bonavida, B., and Chen, S.I.  HTLV-1 gene expression in adult T-cell leukemia cells elicits an NK cell response in vitro and correlates with cell rejection in SCID mice.  Virology 226:167-175, 1996.
  22. Mori, S., Murakami-Mori, K., Jewett, A., Nakamura, S., and Bonavida, B.  Resistance of AIDS-associated Kaposi’s sarcoma cells to Fas-mediated apoptosis.  Cancer Research 56:1874-1879, 1996.
  23. Uslu, R., Jewett, A., and Bonavida, B.  Sensitization by CDDP of human ovarian tumor cells to anti-Fas antibody mediated cytotoxicity and apoptosis.  Gynecologic Oncology 62:282-291, 1996.
  24. Bonavida, B. and Jewett, A.  Natural killer cells in HIV infection. Chapter 17, Immunology of HIV infections,  S. Gupta, ed. Plenum  Press, New York, 353-364, 1996.
  25. Jewett, A., Cavalcanti, M., Giorgi, J., and Bonavida, B.  Concomitant killing in vitro of both gp120 coated CD4+ peripheral T lymphocytes and NK cells in the antibody-dependent cellular cytotoxicity (ADCC) system.  J. Immunol., 158:5492-5500, 1997.
  26. Jewett, A., Cavalcanti, M., and Bonavida, B.  Pivotal role of endogenous TNF-α in the induction of functional inactivation and apoptosis in NK cells.  J. Immunol., 1997,159:4815-4822.
  27. Mori, S., Jewett, A., Murakami-Mori, K., Calvalcanti, M., Bonavida, B., The participation of  the Fas-mediated cytotoxic pathway by natural killer cells is tumor-cell-dependent, Cancer Immunology Immunotherapy. (44): 282-290, 1997.
  28. Jewett, A., Cavalcanti, M., and Bonavida, B.  Expression of CD16 and KIR in NK cells signaled for apoptosis.  Leukocyte Typing VI: Proceedings of the 6th International Workshop/Conference, Japan, 1997, p 298-300.
  29. Jewett, A., Cavalcanti, M., and Bonavida, B.1.  Pivotal role of endogenously synthesized TNF-α by NK cells in regulating  target cell and anti-CD16 mAb mediated apoptosis in NK cells.  Leukocyte Typing VI: Proceedings of the 6th International Workshop/Conference, Japan, 1997,824-826.
  30. Shi W. A. Jewett and W.R. Hume. Rapid and quantitative detection of Streptococcus mutans with species-specific monoclonal antibodies. Hybridoma. (17), 365-371,1998
  31. Shunsuke, M., Jewett, A., Cavalcanti, M., Murakami-Mori, K., Nakamura, S., Bonavida, B., Differential regulation of human NK cell-associated gene expression following activation by IL-2, IFN-α, and PMA/ionomycin. International Journal of Oncology, (12) 1998.
  32. Messadi, D., Jewett, A., Le, A., Berg, S., Wen, Z., Bertolami, C., The role of apoptosis in Keloid Formation, International Journal of Oral Biology, Mar. 1998 : 31-35.
  33. Cavalcanti, M., Jewett, A.,  and Bonavida, B. Irreversible cancer cell-induced functional anergy and apoptosis in resting and activated NK cells. International Journal of Oncology. 14:361-366, 1999.
  34. Messadi, DV; Le, A; Berg, S; Jewett, A; Wen, Z; Kelly, P; Bertolami, CN.  Expression of apoptosis-associated genes by human dermal scar fibroblasts. Wound Repair and Regeneration, 7(6):511-7. 1999
  35. Jewett A and Bonavida B.  MHC class I antigens regulate both the function and survival of human peripheral blood NK cells: Role of endogenously secreted TNF-α.  Clinical Immunology, 96:19-28. 2000
  36. Jewett A, Hume W. R., Ho Le, Huynh T.N., Han Y.W., Cheng G. and W. Shi. Induction of apoptotic cell death in peripheral blood mononuclear cells and polymorphonuclear cells by an oral bacterium Fusobacterium nucleatum.  Infection and Immunity, 68(4): 1893-8, 2000 
  37. M. Ghoneum, A. Jewett. Production of TNF and IFN-γ from human peripheral blood lymphocytes by MGN-3, a modified arabinoxylane from Rice Bran. Cancer Dectection and Prevention. 24 (4): 314-324, 2000.
  38. Reichl FX, Durner J, Hickel R, Kunzelmann KH, Jewett A, Wang MY, Spahl W, Kreppel H, Moes GW, Kehe K, Walther U, Forth W, Hume WR.Distribution and excretion of TEGDMA in guinea pigs and mice. J Dent Res. 2001 May;80(5):1412-5.
  39. Jewett A.  Activation of c-Jun N-terminal kinase in the absence of NFkB function prior to induction of NK cell death triggered by a combination of Anti-Class I and Anti-CD16 antibodies. Human Immunology, Vol. 62 (4) pp. 320-331. (2001).
  40. Jewett A., Wang M, Ziaei P, , Bostanian Z, and No-Hee Park.  Cytokine dependent inverse regulation of CD54 (ICAM1) and Major Histocompatibility Complex Class I (MHC-Class I) antigens by Nuclear Factor kappa B (NFκB) in Hep2 tumor cell line. Effect on the function of Natural Killer cells. Human Immunlogy, 64,505-520,2003
  41. David Han, G. Huang. Anahid Jewett. Expression of HLA-Class II, CD70, CD80, CD86 and proinflammatory cytokines is differentially regulated in oral epithelial cells following bacterial challenge. Oral Microbiology and Immunology, 18: 1-9, 2003
  42. Avina Paranjpe, Leonard Carlos F. Bordador, Mei-ying Wang, Wyatt R. Hume and Anahid Jewett*. Resin monomer 2-hydroxyethyl methacrylate (HEMA) is a potent inducer of apoptotic cell death in human and mouse cells. J Dent Res. 2005, 84(2):172-177
  43. Hiroshi Egusa,  Hiroki Nikawa, Seicho Makihira1, Anahid Jewett, Hirofumi Yatani and Taizo Hamada. Intercellular Adhesion Molecule 1-Dependent Activation of Interleukin 8 Expression in Candida albicans–Infected Human Gingival Epithelial Cells, Infect Immun. 2005, 73(1):622-6.
  44. Kaplan CW, Lux R, Huynh T, Jewett A, Shi W, Haake SK. Fusobacterium nucleatum Apoptosis-inducing Outer Membrane Protein. J Dent Res. Aug;84(8):700-4, 2005
  45. Anahid Jewett, N. A. Cacalano, et al.. “Inhibition of nuclear factor kappa B (NFkappaB) activity in oral tumor cells prevents depletion of NK cells and increases their functional activation.” Cancer Immunol Immunother: 18;1-12. (2005).
  46. Jewett, A,Cacalano NA., Head C and Teruel A, Coengagement of CD16 and CD94 Receptors Mediates Secretion of Chemokines and Induces Apoptotic Death of Naive Natural  Killer Cells. Clin Cancer Res. Apr 1;12(7):1994-2003. 2006
  47. Anahid Jewett, Nicholas A. Cacalano. Emerging mechanisms of immunosuppression in oral cancers. Critical Reviews in Oral Biology and Medicine, J. Dent. R, 85 (12):1061-1073,2006 .
  48. Marcela Romero, Anahid Jewett. Inhibition of TNFα production in TNF-α knock out mice enhances survival and functional activation of immune effectors against oral cancers. Apoptosis, Nov, 12(11): 2063-2075, 2007
  49. Avina Paranjpe, Nicholas A. Cacalano, Wyatt R. Hume and Anahid Jewett. N-acetylcysteine protects Dental Pulp Stromal Cells from HEMA-induced apoptosis by increasing differentiation of the cells. Free Radic Biol Med,  43-1394-1408, 2007
  50. Antonia Teruel, Marcela Romero, Nicholas A. Cacalano, Christian Head,  and Anahid Jewett. Potential contribution of naïve immune effectors to oral tumor resistance: role in synergistic induction of VEGF, IL-6, and IL-8 secretion. Cancer Immunol Immunother: Mar 57(3): 359-366, 2008
  51. Anahid Jewett , Antonia Teruel , Marcela Romero, Christian Head, Nicholas Cacalano. Rapid and potent induction of cell death and loss of NK cell cytotoxicity against oral cancers by F(ab’)2 fragment of anti-CD16 antibody. Cancer Immunol Immunother. , Jul, 57(7):1053-66, 2008
  52. Yamada, N. Kojima, A. Paranjpe, W. Att, H. Aita, A. Jewett, and T. Ogawa, N-acetyl cysteine (NAC)-assisted detoxification of PMMA resin.  J Dent Res. 2008 Apr;87(4):372-377.
  53. Chiachien J Wang, Keisuke Iida, Hiroshi Egusa, Akishige Hokugo, Anahid Jewett, Ichiro Nishimura,  Trabecular Bone Deterioration in col9a1+/- Mice Associated with Enlarged Osteoclasts Adhered to Collagen IX-Deficient Bone.  J Bone Miner Res. 2008, Jun 23 (6): 837-49
  54. Avina Paranjpe, Eric C.Sung, Nicholas A. Cacalano, Wyatt R. Hume and Anahid Jewett. N-acetyl cysteine protects pulp cells from composite restorations in vivo.  J Dent Res. 87(6) 537-541, 2008
  55. Kojima N, Yamada, M, Paranjpe A, Tsukimura N, Kubo K. A. Jewett, and T. Ogawa, Restored viability and function of dental pulp cells on poly emthylmethacrylate (PMMA)- based dental resin supplemented with N-acetyl cysteine (NAC).  Dent. Mater. 2008 Dec;24(12):1686-93. Epub 2008 Jun 9.
  56. J.C. Sitko, B. Yeh, M. Kim, H. Zhou, G. Takaesu, A. Yoshimura, W.H. McBride, A. Jewett, C.A.M. Jamieson and N.A. Cacalano. SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage. Cellular Signaling. 2008 Dec;20(12):2221-30. Epub 2008 Aug 23
  57. Avina Paranjpe, Nicholas A. Cacalano, Wyatt R. Hume and Anahid Jewett. Mechanisms of N-acetyl cysteine-mediated protection from 2-hydroxyethyl methacrylate-induced apoptosis. J.Endod. 2008 Oct;34(10):1191-7. Epub 2008 Aug 23
  59. Nicholas A. Cacalano, David Le, Avina Paranjpe,  Mei-ying Wang, Augustine Fernandez, Tandik Evazyan, No-Hee Park and Anahid Jewett. Regulation of IGFBP6 gene and protein is mediated by the inverse expression and function of c-jun N-terminal kinase (JNK) and NFkappaB in a model of oral tumor cells. Apoptosis, 2008 Dec;13(12):1439-49
  60.  Paranjpe A, Cacalano NA, Hume WR, Jewett A. N-acetyl cysteine (NAC) mediates protection from 2-Hydroxyethyl methacrylate (HEMA) induced apoptosis via NF{kappa}B dependent and independent pathways: Potential involvement of JNK.Toxicol Sci. 2009 Apr;108(2):356-66. Epub 2009 Jan 28
  61. Tsukimura N, Yamada M, Aita H, Hori N, Yoshino F, Chang-Il Lee M, Kimoto K, Jewett A, Ogawa T. N-acetyl cysteine (NAC)-mediated detoxification and functionalization of poly(methyl methacrylate) bone cement. . Biomaterials. 2009 Jul; 30(20):3378-89. Epub 2009 Mar 20
  62. Jewett, A., A. Arasteh, et al. “Strategies to Rescue Mesenchymal Stem Cells (MSCs) and Dental Pulp Stem Cells (DPSCs) from NK Cell Mediated Cytotoxicity.” PLoS One. 2010 Mar 31;5(3):e9874
  63. Mussano F, Lee KJ, Tran L, Zuk P, Cacalano NA, Jewett A, Carossa S, Nishimura I, Differential effect of ionizing radiation exposure on multipotent and differentiation-restricted bone marrow mesenchymal stem cells. J. Cell Biochem. 2010 May 19. [Epub ahead of print]
  64.  Han-Ching Tseng, Aida Arasteh, Avina Paranjpe, Antonia Teruel, Wendy Yang, Armin Behel, Jackelyn Alva, Walters Gina, Christian Head, Tomo-o Ishikawa, Harvey Herschman, Nicholas Cacalano, April Pyle, No-Hee Park, and Anahid Jewett, Increased lysis of stem cells but not their differentiated cells by Natural Killer cells; De-differentiation or reprogramming activates NK cells, PLoS One. 2010 Jul 16;5(7):e11590
  65. Kaplan CW, Ma X, Paranjpe A, Jewett A, Lux R, et al. Fusobacterium nucleatum outer membrane proteins Fap2 and RadD induce cell death in human lymphocytes. Infect Immun 2010. 78(11): 4773-4778.
  67. JOHN A. YAGIELA AND ANAHID JEWETT, Pharmacology and Therepeutics for Dentistry, Immunotherapy, Chapter 41., 2010
  68. Tri N. Huynh6, Radhika V. Kapur1 , Chris W. Kaplan2, Nicholas Cacalano5, Susan K. Haake1, Wenyuan Shi1,2,3, Peter Sieling4, and Anahid Jewett1 The role of aggregation in Fusobacterium nucleatum induced immune cell death. J. Endod. 2011, Nov;37(11):1531-5, Epub 2011 Sep3
  69. Jewett, A. and H.C. Tseng, Tumor induced inactivation of natural killer cell cytotoxic function; implication in growth, expansion and differentiation of cancer stem cells. J Cancer. 2011;2:443-57. Epub 2011 Aug 10.
  70. Anahid Jewett, Han-Ching Tseng, Aida Arasteh, Saba Saadat, Russell E. Christensen and Nicholas A. Cacalano. Natural Killer cells preferentially target cancer stem cells; Role of monocytes in protection against NK cell mediated lysis of cancer stem cells. Curr Drug Deliv.,2011, Oct 21. [Epub ahead of print]
  71. Jewett, A. and H.C. Tseng, Potential rescue, survival and differentiation of cancer stem cells and primary non-transformed stem cells by monocyte-induced split anergy in natural killer cells. Cancer Immunol Immunother. 2012 Feb;61(2):265-74. Epub 2011 Nov 25
  72. Dipak Chaudhari; Eric C. Sung; Avina Paranjpe; and Anahid Jewett , Novel Strategies to Enhance Survival and growth of Pulp cells After Dental Restorations, J Calif Dent Assoc. 2012 May;40(5):409-17
  73. Anahid Jewett*, Hiromi Nakamura, Meiying Wang, Antonia Teruel, Avina Paranjpe and Marcela Romero, Dedifferentiation of Epithelial Tumors Enhances Cytotoxicity, Survival and Expansion of Allogeneic CD8+ T Cells and Natural Killer Cells; J Carcinogen Mutagen 2012, S1, http://dx.doi.org/4172/2157-2518.S1-007
  74. Krifka S, Hiller KA, Spagnuolo G, Jewett A, Schmalz G, Schweikl H. The influence of glutathione on redox regulation by antioxidant proteins and apoptosis in macrophages exposed to 2-hydroxyethyl methacrylate (HEMA).Biomaterials. 2012 Jul;33(21):5177-86. doi: 10.1016/j.biomaterials.2012.04.013. Epub 2012 Apr 24, PMID:22534037 [PubMed – indexed for MEDLINE] 
  75. Anahid Jewett, Yan-Gao Man, Han-Ching Tseng, Dual functions of Natural Killer cells in selection and differentiation of stem cells; Role in regulation of inflammation and regeneration of tissues. J Cancer. 2013;4(1):12-24. doi: 10.7150/jca.5519. Epub 2012 Dec 1 
  76. Man YG, Stojadinovic A, Mason J, Avital I, Bilchik A, Bruecher B, Protic M, Nissan A, Izadjoo M, Zhang X, Jewett A. Tumor-infiltrating immune cells promoting tumor invasion and metastasis: existing theories. J Cancer. 2013;4(1):84-95. doi: 10.7150/jca.5482. Epub 2013 Jan 5
  77. Jiang B, Mason J, Jewett A, Qian J, Ding Y, Cho WC, Zhang X, Man YG. Cell budding from normal appearing epithelia: a predictor of colorectal cancer metastasis. Int J Biol Sci. 2013;9(1):119-33. doi: 10.7150/ijbs.5441. Epub 2013 Jan 11
  78. Anahid Jewett and Han-Ching Tseng, Tumor microenvironment may shape the function and phenotype of NK cells through the induction of split anergy and generation of regulatory NK cells. Chapter 15 “The Tumor microenvironment” Edited by Drs. Michael R. Shurin, Viktor Umansky and Anatoli Malyguine, 2013
  79. Jiang B, Mason J, Jewett A, Cho WC, Man YG. Tube-like structures with co-expression of D2-40 and CD34: newly formed vasculatures. Int J Biol Sci. 2012;8(8):1206-16. doi: 10.7150/ijbs.5147. Epub 2012 Oct 19.
  80. Jewett A. Special issue on immune responses in tumors and non-transformed inflammatory microenvironments. J Cancer. 2013;4(1):1-2. doi: 10.7150/jca.5045. Epub 2012 Nov 30. PMID:23386899
  81. Jiang B, Mason J, Jewett A, Liu ML, Chen W, Qian J, Ding Y, Ding S, Ni M, Zhang X, Man YG. Tumor-infiltrating immune cells: triggers for tumor capsule disruption and tumor progression? Int J Med Sci. 2013;10(5):475-97. doi: 10.7150/ijms.5798. Epub 2013 Mar 5. PMID:23532368 [PubMed – in process]
  82. Tseng HC, Bui V, Man YG, Cacalano N, Jewett A. Induction of Split Anergy Conditions Natural Killer Cells to Promote Differentiation of Stem Cells through Cell-Cell Contact and Secreted Factors. Front Immunol. 2014 Jun 19;5:269. doi: 10.3389/fimmu.2014.00269. eCollection 2014. PMID: 24995006, [PubMed]
  83. Song G, Hsiao H, Wang JL, Mannion C, Stojadinovic A, Avital I, Fu SW, Mason J, Chen W, Jewett A, Li H, Man YG. Differential impact of tumor-infiltrating immune cells on basal and luminal cells: implications for tumor invasion and metastasis. Anticancer Res. 2014 Nov;34(11):6363-80. PMID: 25368236
  84. Perišić Nanut M, Sabotič J, Jewett A, Kos J. Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells. Front Immunol. 2014 Dec 2;5:616. doi: 10.3389/fimmu.2014.00616. eCollection 2014. Review. PMID: 25520721
  85. Yan-gao Man, Jinlian Wang, Jeffrey Mason, Ciaran Mannion, Sidney Fu, Anahid Jewett, Izhak, Avital, Alexander Stojadinovic. Can current cell sorting methods capture cancer invasion and metastasis-causing stem cells? New Approaches combating Cancer & Aging,  2014; 1(1): 1-21.
  86. Jiang B, Avital I, Bilchik A,, Nissan A, Mason J, Chen W, Mannion C, Jewett A, Wang JL, Stojadinovic A, Man YG Differential lymphatic involvement in primary site of node positive and negative colorectal cancer
    New Approaches combating Cancer & Aging 2014; 1(1): 29-45.
  87. Shurin MR, Umansky V, Malyguine A, Hurwitz AA, Apte RN, Whiteside T, Jewett A, Thanavala Y, Murphy WJ.  Cellular and molecular pathways in the tumor immunoenvironment: 3rd Cancer Immunotherapy and Immunomonitoring (CITIM) meeting, 22-25 April 2013, Krakow, Poland. Cancer Immunol Immunother. 2014 Jan;63(1):73-80. doi: 10.1007/s00262-013-1501-z. Epub 2013 Nov 24. PMID: 24271210
  88. Jewett A, Man YG, Cacalano N, Kos J, Tseng HC. Natural killer cells as effectors of selection and differentiation of stem cells: Role in resolution of inflammation. [Published online ahead of print February 27, 2014] J Immunotoxicol doi: 103109/1547691X2013877104.
  89. Tseng, H., Cacalano, N., & Jewett, A. (2015). Split anergized Natural Killer cells halt inflammation by inducing stem cell differentiation, resistance to NK cell cytotoxicity and prevention of cytokine and chemokine secretion. Oncotarget, 6(11), 8947-8959. 
  90. Park S, Kanayama K, Kaur K, Tseng HC, Banankhah S, Quje DT, Sayre JW, Jewett A, Nishimura I. Osteonecrosis of the Jaw Developed in Mice: DISEASE VARIANTS REGULATED BY γδ T CELLS IN ORAL MUCOSAL BARRIER IMMUNITY. J Biol Chem. 2015 Jul 10;290(28):17349-66. doi: 10.1074/jbc.M115.652305. Epub 2015 May 26.PMID:26013832
  91. Halder RC, Almasi A, Sagong B, Leung J, Jewett A, Fiala M. Curcuminoids and ω-3 fatty acids with anti-oxidants potentiate cytotoxicity of natural killer cells against pancreatic ductal adenocarcinoma cells and inhibit interferon γ production. Front Physiol. 2015 May 22;6:129. doi: 10.3389/fphys.2015.00129. eCollection 2015. PMID: 26052286
  92. Tseng HC, Arasteh A, Kaur K, Kozlowska A, Topchyan P, Jewett A. Differential Cytotoxicity but Augmented IFN-γ Secretion by NK Cells after Interaction with Monocytes from Humans, and Those from Wild Type and Myeloid-Specific COX-2 Knockout Mice. Front Immunol. 2015 Jun 9;6:259. doi: 10.3389/fimmu.2015.00259. eCollection 2015. PMID: 26106386
  93. Magister, S., Tseng, H., Bui, V., Kos, J., & Jewett, A. (2015). Regulation of split anergy in natural killer cells by inhibition of cathepsins C and H and cystatin F. Oncotarget, 5. 2015 Sep 8;6(26):22310-27
  94. Han-Ching Tseng1&; Keiichi Kanayama2,3&; Kawaljit Kaur1&; So-Hyun Park1, Sil Park1,2; Anna Kozlowska4; Shuting Sun5, Charles E. McKenna5, Ichiro Nishimura**1,2 and Anahid Jewett*1.Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo; Role in osteoclast-mediated NK cell activation. Oncotarget, 2015 Aug 21;6(24):20002-25
  95. Han-Ching Tseng, Akihito Inagaki, Vickie T. Bui, Nicholas Cacalano, Noriyuki Kasahara, Yan-gao Man and Anahid JewettDifferential Targeting of Stem Cells and Differentiated Glioblastomas by NK Cells,                Journal of Cancer, 2015; 6(9): 866-876. doi: 10.7150/jca.11527
  96. Bui, V. T., H.-C. Tseng, P. O. Maung, A. Kozlowska, K. Mann, P. Topchyan and A. Jewett. “Augmented IFN-γ and TNF-α Induced by Probiotic Bacteria in NK Cells Mediate Differentiation of Stem-Like Tumors Leading to Inhibition of Tumor Growth and Reduction in Inflammatory Cytokine Release; Regulation by IL-10.” Frontiers in Immunology, 6:576.doi: 10.3389/fimmu. 2015.00576
  97. Rezzadeh KS, Hokugo A, Jewett A, Kozlowska A, Segovia LA, Zuk P, Jarrahy R. Natural Killer Cells Differentiate Human Adipose-Derived Stem Cells and Modulate Their Adipogenic Potential. 
  98. Plast Reconstr Surg. 2015 Sep;136(3):503-10. doi: 10.1097/PRS.0000000000001536. PMID: 26313823
  99. Marcela Romero Reyes and Anahid Jewett, Increased activation and survival of immune effectors during anti-TNF-α therapy: Lessons learned from TNF-/- mice; New Approaches combating Cancer & Aging 2015; 2: 76-88
  101. ANAHID JEWETT and Han-Ching Tseng, Pharmacology and Therepeutics for Dentistry, 7e, Immunotherapy, Chapter 35, 2015
  102. Natalia Aptsiauri, Anahid Jewett, Arthur A. Hurwitz, Michael R. Shurin, Viktor Umansky.  Redefining cancer immunotherapy – optimization, personalization and new predictive biomarkers: 4th Cancer Immunotherapy and Immunomonitoring (CITIM) meeting, 27–30 April 2015, Ljubljana, Slovenia, Cancer Immunology and Immunotherapy, 2016 Jul;65(7):835-45. doi: 10.1007/s00262-016-1822-9. Epub 2016 Mar 31. Review.
  103. Kozlowska AK, Kaur K, Topchyan P, Jewett A, Adoptive transfer of osteoclast-expanded natural killer cells for immunotherapy targeting cancer stem-like cells in humanized mice. Cancer Immunol Immunother. 2016 Jul;65(7):835-45. doi: 10.1007/s00262-016-1822-9. Epub 2016 Mar 31. Review
  104.  
  105. Latham J, Fong H, Jewett A, Johnson JD, Paranjpe A. Disinfection Efficacy of Current Regenerative Endodontic Protocols in Simulated Necrotic Immature Permanent Teeth. J Endod. 2016 Jun 29. pii: S0099-2399(16)30248-5. doi: 10.1016/j.joen.2016.05.004. [Epub ahead of print], PMID: 27372159
  106. Anna K. Kozlowska, Han-Ching Tseng, Kawaljit Kaur, Paytsar Topchyan, Akihito Inagaki, Vickie T. Bui, Noriyuki Kasahara, Nicholas Cacalano and Anahid Jewett Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-g after differentiation of glioblastoma by human natural killer cells; Cancer Immunology and Immunotherapy; 2016; 65(9): 1085-97 
  107. Yujie Sun, Kawaljit Kaur, Keiichi Kanayama, Kenzo Morinaga, Sil Park, Akishige, Hokugo, Anna Kozlowska, William H. McBride, Jun Li, Anahid Jewett, Ichiro Nishimura.  Plasticity of Myeloid Cells during Oral Barrier Wound Healing and the Development of Bisphosphonate-Related Osteonecrosis of the Jaw. J Biol Chem. 2016 Aug 11. pii: jbc.M116.735795. [Epub ahead of print
  108. Anna K. Kozlowska, Kawaljit Kaur , Paytsar Topchyan, Anahid Jewett, Novel strategies to target cancer stem cells by NK cells; studies in humanized mice; Frontiers in bioscience (Landmark edition), 2017; 22: 370-384.
  109. Kaur K, Cook J, Park S, Topchyan P, Kozlowska A, Ohanian N, Fang C, Nishimura I and Jewett A (2017). Novel strategy to expand super-charged NK cells with significant potential to lyse and differentiate cancer stem cells; Differences in NK expansion and function between healthy and cancer patients. Front. Immunol 7:9. doi: 10.3389/fonc.2017.00009
  110. Anna Kozlowska, Paytsar Topchyan, Kawaljit Kaur, Han-Ching Tseng, Antonia Teruel, Toru Hiraga, and Anahid Jewett, Differentiation by NK cells is a prerequisite for effective targeting of cancer stem cells/poorly differentiated tumors by chemopreventive and chemotherapeutic drugs; Journal of Cancer, 2017; 8(4): 537-554. doi: 10.7150/jca.15989
  111. Milica M Perisic Nanut, Jerics Sabotič, Urban Svajger, Anahid Jewett, Janko Kos; Cystatin F affects natural killer cell cytotoxicity, ” Frontiers in Immunology” 2017 Nov 13;8:1459. doi: 10.3389/fimmu.2017.01459. eCollection 2017.
  112.  Kawaljit Kaur1, Hui-Hua Chang1, Jessica Cook1, Guido Eibl1, Anahid Jewett; Suppression of Gingival NK Cells in Precancerous and Cancerous Stages of Pancreatic Cancer in KC and BLT-Humanized Mice. ” Frontiers in Immunology” 2017 Dec 4;8:1606. doi: 10.3389/fimmu.2017.01606. eCollection 2017.
  113. Kawaljit Kaur1, Hui-Hua Chang2, Paytsar Topchyan1, Jessica Morgan Cook1, Andre Barkhordarian1, Guido Eibl2 and Anahid Jewett1,3,4*Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice, Front Immunol. 2018; 9: 1229.
  114. Kaur, K., P. Topchyan, A. K. Kozlowska, N. Ohanian, J. Chiang, P. O. Maung, S.-H. Park, M.-W. Ko, C. Fang, I. Nishimura and A. Jewett (2018). “Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated oral tumors in vivo in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs. Oncoimmunology. 2018 Feb 22;7(5):e1426518. doi: 10.1080/2162402X.2018.1426518. eCollection 2018
  115. Jewett A. Editorial overview: Tumour immunology: Are we on the path to win the battle against cancer through immunotherapy? Curr Opin Immunol. 2018 Apr;51:vii-ix. doi: 10.1016/j.coi.2018.04.018.
  116. Kawaljit Kaur1, Milica Perišić Nanut2, Mengwei Ko1, Tahmineh Safaie1, Janko Kos2,3 and Anahid Jewett1,4* Natural killer cells target and differentiate cancer stem-like cells/undifferentiated tumors: strategies to optimize their growth and expansion for effective cancer immunotherapy.; Curr Opin Immunol. 2018 Apr;51:170-180. doi: 10.1016/j.coi.2018.03.022. Epub 2018 Apr 10.
  117. Janko Kos1,2 · Milica Perišić Nanut1 · Mateja Prunk1 · Jerica Sabotič1 · Esmeralda Dautović3 · Anahid Jewett4. Cystatin F as a regulator of immune cell cytotoxicity; Cancer Immunology and Immunotherapy; 2018. 67(12): p. 1931-1938 
  118. Pislar, A., A. Jewett, and J. Kos, Cysteine cathepsins: Their biological and molecular significance in cancer stem cells. Semin Cancer Biol, 2018. 53: p. 168-177.
  119. Anahid Jewett1,2*, Janko Kos3,4, Yuman Fong5,6, Meng-Wei Ko1, Tahmineh Safaei1, Andre Barkhordarian1, Milica Perišić Nanut3, Kawaljit Kaur1 , NK cells shape pancreatic and oral tumor microenvironments; role in inhibition of tumor growth and metastasis. Seminars in Cancer Biology, , 2018. 53: p. 178-188
  120. Anahid Jewett 1,2* Janko Kos3,4 , Mengwei Ko1, Tahmineh Safaei1, Omid Nikjah1, Majed Bamatraf1, Paul Wong1, Artin Keshishian Namagerdi1, and Kawaljit Kaur 1 Natural killer cells pave the road for effective targeting of cancer; inhibition of their effector function at the pre-neoplastic and neoplastic stages of tumorigenesis;  Translational Research: Recent Progress and Future Directions;  editor; Francesco Chiappelli; Book chapter, Nova Science Publishers, Incorporated, Nov 29, 2018 – 345 pages https://books.google.com/books/about/Translational_Research.html?id=FwJfvQEACAAJ&source=kp_cover
  121. Jakos, T., Anja Pislar, Anahid Jewett and Janko Kos, Cysteine Cathepsins in Tumor-Associated Immune Cells. Front Immunol, 2019. 10: p. 2037.
  122. Wang, D., Kawaljit Kaur, Avina Paranjpe, Eric Lee, Matthew Wasilewski, Danielle Sung, David Han, Eric C. Sung and Anahid Jewett., N-acetyl cysteine prevents pain and hypersensitivity of bleaching agents without affecting their aesthetic appeal; evidence from in vitro to animal studies and to human clinical trials. Translational Medicine Communications, 2019. 4(1): p. 19.
  123. Anahid Jewett, Janko Kos, Kawaljit Kaur, Tahmineh Safaei, Christine Sutanto, Wuyang Chen, Paul Wong, Artin Keshishian Namagerdi, Changge Fang, Yuman Fong, Meng-Wei Ko, Natural killer cells; diverse functions in tumor immunity and defects in pre-neoplastic and neoplastic stages of tumorigenesis. Molecular Therapy: Oncolytics, https://doi.org/10.1016/j.omto.2019.11.002
  124. Kawaljit Kaur, Anna Karolina Kozlowska, Paytsar Topchyan, Meng‐Wei Ko, Nick Ohanian, Jessica Chiang ,Jessica Cook, Phyu Ou Maung, So‐Hyun Park, Nicholas Cacalano, Changge Fang and Anahid Jewett. Probiotic‐Treated Super‐Charged NK Cells Efficiently Clear Poorly Differentiated Pancreatic Tumors in Hu‐BLT Mice.Cancers 2020, 12, 63; doi:10.3390/cancers12010063  (https://doi.org/10.3390/cancers12010063)
  125. Anahid Jewett, Janko Kos, Kawaljit Kaur1, Tamara Leh Turnsek1,5 , Barbara Breznik1,5, Emanuela Senjor1,3,4, Paul Wong1, Kristin Y Nguyen1, Meng-Wei Ko1, Multiple defects of Natural Killer cells in cancer patients; Anarchy and dysregulated systemic immunity and immunosuppression in metastatic cancer; Critical Reviews in Immunology, 2019 “In press”
  126. Giulia Negro, Bertram Aschenbrenner, Simona Kranjc Brezar, Maja Čemažar, Andrej Coe, Gorana Gašljević, Dragana Savic1, Maxim Sorokin, Anton Buzdin, Maurizio Callari, Irma Kvitsaridze , Anahid Jewett, Mariela Vasileva-Slaveva, Ute Ganswindt, Ira Skvortsova, Sergej Skvortsov, Molecular heterogeneity in breast carcinoma cells with increased invasiveness. Radiology and Oncology. 2019 “In press”

Publications separated by type

  1. Wright, S.C., Jewett, A., Mitsuyasu, R., and Bonavida, B.  Spontaneous cytotoxicity and TNF production by peripheral blood monocytes from AIDS patients.  J. Immunol.  141: 99-104, 1988.
  2. Bonavida, B. and Jewett, A.  Activation of human peripheral blood derived monocytes by OK432  (Streptococcus pyogenes).  Augmented cytotoxicity and secretion of TNF and synergy with rIFN-.  Cell. Immunol.  123:373-383, 1989.
  3. Jewett, A. and Bonavida, B.  Peripheral blood monocytes derived from HIV+ individuals mediate antibody dependent cellular cytotoxicity. Clin. Immunol. Immunopath.  54:192-199, 1990.
  4. Jewett, A., Giorgi, J.V., and Bonavida, B.  Antibody dependent cellular cytotoxicity (ADCC) against HIV-coated target cells by peripheral blood monocytes from HIV seropositive asymptomatic patients.  J. Immunol. 145:4065-4071, 1990.
  5. Gan, X.-H., Jewett, A., and Bonavida, B.  Activation of human peripheral blood derived monocytes by CDDP:  Enhanced tumoricidal activity and secretion of TNF-.  Nat. Imm. Cell Growth Reg. 11:144-155, 1992.
  6. Lebow, L.T., Jewett, A., and Bonavida, B.  Killer cell recruitment and renewal capacity of purified cytolytic and non-cytolytic human peripheral blood natural killer cell subsets.  J. Immunol. 150:320-329, 1993.
  7. Bonavida, B., Lebow, J.T., and Jewett, A.  Natural Killer cell subsets: Maturation, differentiation and regulation.  Nat. Immunity 12:194-208, 1993.
  8. Jewett, A. and Bonavida, B.  Pivotal role of endogenous TNF- in the IL-2 driven activation and proliferation of the functionally immature NK Free subset.  Cell. Immunol. 151, 257-269, 1993.
  9. Bonavida, B., Braquet, M., Lebow, L.T., and Jewett, A.  Qualitative and quantitative analysis of subpopulations of cytotoxic effector cells by flow cytometry.  J. Lipid Mediators.  9:19-25, 1994.
  10. Jewett, A. and Bonavida, B.  Activation of the human immature natural killer subset by IL-12 and its regulation by endogenous TNF- and IFN- secretion.  Cell. Immunol. 154:273-286, 1994.
  11. Jewett, A. and Bonavida, B.  Pentoxfylline suppresses  IL-2 mediated activation of immature human natural killer cells by inhibiting endogenous TNF- secretion.  J. Clin. Immunol.   14(1):31-38, 1994.
  12. Hober, D., Jewett, A., and Bonavida, B.  Lysis of uninfected HIV-gp120 coated peripheral blood derived T lymphocytes by monocyte-mediated antibody dependent cellular cytotoxicity.  FEMS Immunol. & Med. Microbiol. 10:83-92, 1995.
  13. Jewett, A. and Bonavida, B.  Target-induced anergy of Natural Killer cytotoxic function is restricted to the NK-target conjugate subset.  Cell. Immunol.  160:91-97, 1995.
  14. Jewett, A. and Bonavida, B.  Interferon- activates cytotoxic function but inhibits interleukin-2 mediated proliferation and tumor necrosis factor- secretion of immature human natural killer cells.  J. Clin. Immunol.  15:35-44, 1995.
  15. Hu, P.F., Hultin, L.E., Hultin, P., Hausner, M.A., Hirji, K., Jewett, A., Bonavida, B., Detels, R., and Giorgi, J.V.  Natural killer cell immunodeficiency in HIV disease is manifest by profoundly decreased number of CD16+CD56+ cells and expansion of a population of CD16dimCD56– cells with low lytic activity.  J. Acquired Immune Deficiency Syndromes and Human Retrovirology  10:331-340, 1995.
  16. Jewett, A. and Bonavida, B.  Target-induced split anergy and apoptosis in a subset of human natural killer cells.  J. Immunol. 156:907-915, 1996.
  17. Jewett, A., Gan, X.H., Lebow, L., and Bonavida, B.  Differential secretion of TNF- and IFN-g by human peripheral blood-derived NK subsets and association with functional maturation.  J. Clin. Immunol.  16:46-54,1996.
  18. Stewart, S.A., Fruer, G., Jewett, A., Lee, F.V., Bonavida, B., and Chen, S.I.  HTLV-1 gene expression in adult T-cell leukemia cells elicits an NK cell response in vitro and correlates with cell rejection in SCID mice.  Virology 226:167-175, 1996.
  19. Mori, S., Murakami-Mori, K., Jewett, A., Nakamura, S., and Bonavida, B.  Resistance of AIDS-associated Kaposi’s sarcoma cells to Fas-mediated apoptosis.  Cancer Research 56:1874-1879, 1996.
  20. Uslu, R., Jewett, A., and Bonavida, B.  Sensitization by CDDP of human ovarian tumor cells to anti-Fas antibody mediated cytotoxicity and apoptosis.  Gynecologic Oncology 62:282-291, 1996.
  21. Jewett, A., Cavalcanti, M., Giorgi, J., and Bonavida, B.  Concomitant killing in vitro of both gp120 coated CD4+ peripheral T lymphocytes and NK cells in the antibody-dependent cellular cytotoxicity (ADCC) system.  J. Immunol., 158:5492-5500, 1997.
  22. Jewett, A., Cavalcanti, M., and Bonavida, B.  Pivotal role of endogenous TNF-α in the induction of functional inactivation and apoptosis in NK cells.  J. Immunol., 1997,159:4815-4822.
  23. Mori, S., Jewett, A., Murakami-Mori, K., Calvalcanti, M., Bonavida, B., The participation of  the Fas-mediated cytotoxic pathway by natural killer cells is tumor-cell-dependent, Cancer Immunology Immunotherapy. (44): 282-290, 1997.
  24. Shi W. A. Jewett and W.R. Hume. Rapid and quantitative detection of Streptococcus mutans with species-specific monoclonal antibodies. Hybridoma. (17), 365-371,1998
  25. Shunsuke, M., Jewett, A., Cavalcanti, M., Murakami-Mori, K., Nakamura, S., Bonavida, B., Differential regulation of human NK cell-associated gene expression following activation by IL-2, IFN-α, and PMA/ionomycin. International Journal of Oncology, (12) 1998.
  26. Messadi, D., Jewett, A., Le, A., Berg, S., Wen, Z., Bertolami, C., The role of apoptosis in Keloid Formation, International Journal of Oral Biology, Mar. 1998 : 31-35.
  27. Cavalcanti, M., Jewett, A.,  and Bonavida, B. Irreversible cancer cell-induced functional anergy and apoptosis in resting and activated NK cells. International Journal of Oncology. 14:361-366, 1999.
  28. Messadi, DV; Le, A; Berg, S; Jewett, A; Wen, Z; Kelly, P; Bertolami, CN.  Expression of apoptosis-associated genes by human dermal scar fibroblasts. Wound Repair and Regeneration, 7(6):511-7. 1999
  29. Jewett A and Bonavida B.  MHC class I antigens regulate both the function and survival of human peripheral blood NK cells: Role of endogenously secreted TNF-α.  Clinical Immunology, 96:19-28. 2000
  30. Jewett A, Hume W. R., Ho Le, Huynh T.N., Han Y.W., Cheng G. and W. Shi. Induction of apoptotic cell death in peripheral blood mononuclear cells and polymorphonuclear cells by an oral bacterium Fusobacterium nucleatum.  Infection and Immunity, 68(4): 1893-8, 2000 
  31. M. Ghoneum, A. Jewett. Production of TNF and IFN-γ from human peripheral blood lymphocytes by MGN-3, a modified arabinoxylane from Rice Bran. Cancer Dectection and Prevention. 24 (4): 314-324, 2000.
  32. Reichl FX, Durner J, Hickel R, Kunzelmann KH, Jewett A, Wang MY, Spahl W, Kreppel H, Moes GW, Kehe K, Walther U, Forth W, Hume WR.Distribution and excretion of TEGDMA in guinea pigs and mice. J Dent Res. 2001 May;80(5):1412-5.
  33. Jewett A.  Activation of c-Jun N-terminal kinase in the absence of NFkB function prior to induction of NK cell death triggered by a combination of Anti-Class I and Anti-CD16 antibodies. Human Immunology, Vol. 62 (4) pp. 320-331. (2001).
  34. Jewett A., Wang M, Ziaei P, , Bostanian Z, and No-Hee Park.  Cytokine dependent inverse regulation of CD54 (ICAM1) and Major Histocompatibility Complex Class I (MHC-Class I) antigens by Nuclear Factor kappa B (NFκB) in Hep2 tumor cell line. Effect on the function of Natural Killer cells. Human Immunlogy, 64,505-520,2003
  35. David Han, G. Huang. Anahid Jewett. Expression of HLA-Class II, CD70, CD80, CD86 and proinflammatory cytokines is differentially regulated in oral epithelial cells following bacterial challenge. Oral Microbiology and Immunology, 18: 1-9, 2003
  36. Avina Paranjpe, Leonard Carlos F. Bordador, Mei-ying Wang, Wyatt R. Hume and Anahid Jewett*. Resin monomer 2-hydroxyethyl methacrylate (HEMA) is a potent inducer of apoptotic cell death in human and mouse cells. J Dent Res. 2005, 84(2):172-177
  37. Hiroshi Egusa,  Hiroki Nikawa, Seicho Makihira1, Anahid Jewett, Hirofumi Yatani and Taizo Hamada. Intercellular Adhesion Molecule 1-Dependent Activation of Interleukin 8 Expression in Candida albicans–Infected Human Gingival Epithelial Cells, Infect Immun. 2005, 73(1):622-6.
  38. Kaplan CW, Lux R, Huynh T, Jewett A, Shi W, Haake SK. Fusobacterium nucleatum Apoptosis-inducing Outer Membrane Protein. J Dent Res. Aug;84(8):700-4, 2005
  39. Anahid Jewett, N. A. Cacalano, et al.. “Inhibition of nuclear factor kappa B (NFkappaB) activity in oral tumor cells prevents depletion of NK cells and increases their functional activation.” Cancer Immunol Immunother: 18;1-12. (2005).
  40. Jewett, A,Cacalano NA., Head C and Teruel A, Coengagement of CD16 and CD94 Receptors Mediates Secretion of Chemokines and Induces Apoptotic Death of Naive Natural  Killer Cells. Clin Cancer Res. Apr 1;12(7):1994-2003. 2006
  41. Marcela Romero, Anahid Jewett. Inhibition of TNFα production in TNF-α knock out mice enhances survival and functional activation of immune effectors against oral cancers. Apoptosis, Nov, 12(11): 2063-2075, 2007
  42. Avina Paranjpe, Nicholas A. Cacalano, Wyatt R. Hume and Anahid Jewett. N-acetylcysteine protects Dental Pulp Stromal Cells from HEMA-induced apoptosis by increasing differentiation of the cells. Free Radic Biol Med,  43-1394-1408, 2007
  43. Antonia Teruel, Marcela Romero, Nicholas A. Cacalano, Christian Head,  and Anahid Jewett. Potential contribution of naïve immune effectors to oral tumor resistance: role in synergistic induction of VEGF, IL-6, and IL-8 secretion. Cancer Immunol Immunother: Mar 57(3): 359-366, 2008
  44. Anahid Jewett , Antonia Teruel , Marcela Romero, Christian Head, Nicholas Cacalano. Rapid and potent induction of cell death and loss of NK cell cytotoxicity against oral cancers by F(ab’)2 fragment of anti-CD16 antibody. Cancer Immunol Immunother. , Jul, 57(7):1053-66, 2008
  45. Yamada, N. Kojima, A. Paranjpe, W. Att, H. Aita, A. Jewett, and T. Ogawa, N-acetyl cysteine (NAC)-assisted detoxification of PMMA resin.  J Dent Res. 2008 Apr;87(4):372-377.
  46. Chiachien J Wang, Keisuke Iida, Hiroshi Egusa, Akishige Hokugo, Anahid Jewett, Ichiro Nishimura,  Trabecular Bone Deterioration in col9a1+/- Mice Associated with Enlarged Osteoclasts Adhered to Collagen IX-Deficient Bone.  J Bone Miner Res. 2008, Jun 23 (6): 837-49
  47. Avina Paranjpe, Eric C.Sung, Nicholas A. Cacalano, Wyatt R. Hume and Anahid Jewett. N-acetyl cysteine protects pulp cells from composite restorations in vivo.  J Dent Res. 87(6) 537-541, 2008
  48. Kojima N, Yamada, M, Paranjpe A, Tsukimura N, Kubo K. A. Jewett, and T. Ogawa, Restored viability and function of dental pulp cells on poly emthylmethacrylate (PMMA)- based dental resin supplemented with N-acetyl cysteine (NAC).  Dent. Mater. 2008 Dec;24(12):1686-93. Epub 2008 Jun 9.
  49. J.C. Sitko, B. Yeh, M. Kim, H. Zhou, G. Takaesu, A. Yoshimura, W.H. McBride, A. Jewett, C.A.M. Jamieson and N.A. Cacalano. SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage. Cellular Signaling. 2008 Dec;20(12):2221-30. Epub 2008 Aug 23
  50. Avina Paranjpe, Nicholas A. Cacalano, Wyatt R. Hume and Anahid Jewett. Mechanisms of N-acetyl cysteine-mediated protection from 2-hydroxyethyl methacrylate-induced apoptosis. J.Endod. 2008 Oct;34(10):1191-7. Epub 2008 Aug 23
  51. Nicholas A. Cacalano, David Le, Avina Paranjpe,  Mei-ying Wang, Augustine Fernandez, Tandik Evazyan, No-Hee Park and Anahid Jewett. Regulation of IGFBP6 gene and protein is mediated by the inverse expression and function of c-jun N-terminal kinase (JNK) and NFkappaB in a model of oral tumor cells. Apoptosis, 2008 Dec;13(12):1439-49
  52.  Paranjpe A, Cacalano NA, Hume WR, Jewett A. N-acetyl cysteine (NAC) mediates protection from 2-Hydroxyethyl methacrylate (HEMA) induced apoptosis via NF{kappa}B dependent and independent pathways: Potential involvement of JNK.Toxicol Sci. 2009 Apr;108(2):356-66. Epub 2009 Jan 28
  53. Tsukimura N, Yamada M, Aita H, Hori N, Yoshino F, Chang-Il Lee M, Kimoto K, Jewett A, Ogawa T. N-acetyl cysteine (NAC)-mediated detoxification and functionalization of poly(methyl methacrylate) bone cement. . Biomaterials. 2009 Jul; 30(20):3378-89. Epub 2009 Mar 20
  54. Jewett, A., A. Arasteh, et al. “Strategies to Rescue Mesenchymal Stem Cells (MSCs) and Dental Pulp Stem Cells (DPSCs) from NK Cell Mediated Cytotoxicity.” PLoS One. 2010 Mar 31;5(3):e9874.
  55. Mussano F, Lee KJ, Tran L, Zuk P, Cacalano NA, Jewett A, Carossa S, Nishimura I, Differential effect of ionizing radiation exposure on multipotent and differentiation-restricted bone marrow mesenchymal stem cells. J. Cell Biochem. 2010 May 19. [Epub ahead of print]
  56.  Han-Ching Tseng, Aida Arasteh, Avina Paranjpe, Antonia Teruel, Wendy Yang, Armin Behel, Jackelyn Alva, Walters Gina, Christian Head, Tomo-o Ishikawa, Harvey Herschman, Nicholas Cacalano, April Pyle, No-Hee Park, and Anahid Jewett, Increased lysis of stem cells but not their differentiated cells by Natural Killer cells; De-differentiation or reprogramming activates NK cells, PLoS One. 2010 Jul 16;5(7):e11590
  57. Kaplan CW, Ma X, Paranjpe A, Jewett A, Lux R, et al. Fusobacterium nucleatum outer membrane proteins Fap2 and RadD induce cell death in human lymphocytes. Infect Immun 2010. 78(11): 4773-4778.
  58. Tri N. Huynh6, Radhika V. Kapur1 , Chris W. Kaplan2, Nicholas Cacalano5, Susan K. Haake1, Wenyuan Shi1,2,3, Peter Sieling4, and Anahid Jewett1 The role of aggregation in Fusobacterium nucleatum induced immune cell death. J. Endod. 2011, Nov;37(11):1531-5, Epub 2011 Sep3
  59. Dipak Chaudhari; Eric C. Sung; Avina Paranjpe; and Anahid Jewett , Novel Strategies to Enhance Survival and growth of Pulp cells After Dental Restorations, J Calif Dent Assoc. 2012 May;40(5):409-17
  60. Anahid Jewett*, Hiromi Nakamura, Meiying Wang, Antonia Teruel, Avina Paranjpe and Marcela Romero, Dedifferentiation of Epithelial Tumors Enhances Cytotoxicity, Survival and Expansion of Allogeneic CD8+ T Cells and Natural Killer Cells; J Carcinogen Mutagen 2012, S1, http://dx.doi.org/4172/2157-2518.S1-007
  61. Krifka S, Hiller KA, Spagnuolo G, Jewett A, Schmalz G, Schweikl H. The influence of glutathione on redox regulation by antioxidant proteins and apoptosis in macrophages exposed to 2-hydroxyethyl methacrylate (HEMA).Biomaterials. 2012 Jul;33(21):5177-86. doi: 10.1016/j.biomaterials.2012.04.013. Epub 2012 Apr 24, PMID:22534037 [PubMed – indexed for MEDLINE] 
  62. Anahid Jewett, Yan-Gao Man, Han-Ching Tseng, Dual functions of Natural Killer cells in selection and differentiation of stem cells; Role in regulation of inflammation and regeneration of tissues. J Cancer. 2013;4(1):12-24. doi: 10.7150/jca.5519. Epub 2012 Dec 1 
  63. Man YG, Stojadinovic A, Mason J, Avital I, Bilchik A, Bruecher B, Protic M, Nissan A, Izadjoo M, Zhang X, Jewett A. Tumor-infiltrating immune cells promoting tumor invasion and metastasis: existing theories. J Cancer. 2013;4(1):84-95. doi: 10.7150/jca.5482. Epub 2013 Jan 5
  64. Jiang B, Mason J, Jewett A, Qian J, Ding Y, Cho WC, Zhang X, Man YG. Cell budding from normal appearing epithelia: a predictor of colorectal cancer metastasis. Int J Biol Sci. 2013;9(1):119-33. doi: 10.7150/ijbs.5441. Epub 2013 Jan 11
  65. Jiang B, Mason J, Jewett A, Cho WC, Man YG. Tube-like structures with co-expression of D2-40 and CD34: newly formed vasculatures. Int J Biol Sci. 2012;8(8):1206-16. doi: 10.7150/ijbs.5147. Epub 2012 Oct 19.
  66. Jewett A. Special issue on immune responses in tumors and non-transformed inflammatory microenvironments. J Cancer. 2013;4(1):1-2. doi: 10.7150/jca.5045. Epub 2012 Nov 30. PMID:23386899
  67. Jiang B, Mason J, Jewett A, Liu ML, Chen W, Qian J, Ding Y, Ding S, Ni M, Zhang X, Man YG. Tumor-infiltrating immune cells: triggers for tumor capsule disruption and tumor progression? Int J Med Sci. 2013;10(5):475-97. doi: 10.7150/ijms.5798. Epub 2013 Mar 5. PMID:23532368 [PubMed – in process]
  68. Tseng HC, Bui V, Man YG, Cacalano N, Jewett A. Induction of Split Anergy Conditions Natural Killer Cells to Promote Differentiation of Stem Cells through Cell-Cell Contact and Secreted Factors. Front Immunol. 2014 Jun 19;5:269. doi: 10.3389/fimmu.2014.00269. eCollection 2014. PMID: 24995006, [PubMed]
  69. Song G, Hsiao H, Wang JL, Mannion C, Stojadinovic A, Avital I, Fu SW, Mason J, Chen W, Jewett A, Li H, Man YG. Differential impact of tumor-infiltrating immune cells on basal and luminal cells: implications for tumor invasion and metastasis. Anticancer Res. 2014 Nov;34(11):6363-80. PMID: 25368236
  70. Perišić Nanut M, Sabotič J, Jewett A, Kos J. Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells. Front Immunol. 2014 Dec 2;5:616. doi: 10.3389/fimmu.2014.00616. eCollection 2014. Review. PMID: 25520721
  71. Yan-gao Man, Jinlian Wang, Jeffrey Mason, Ciaran Mannion, Sidney Fu, Anahid Jewett, Izhak, Avital, Alexander Stojadinovic. Can current cell sorting methods capture cancer invasion and metastasis-causing stem cells? New Approaches combating Cancer & Aging,  2014; 1(1): 1-21.
  72. Jiang B, Avital I, Bilchik A,, Nissan A, Mason J, Chen W, Mannion C, Jewett A, Wang JL, Stojadinovic A, Man YG Differential lymphatic involvement in primary site of node positive and negative colorectal cancer
    New Approaches combating Cancer & Aging 2014; 1(1): 29-45.
  73. Tseng, H., Cacalano, N., & Jewett, A. (2015). Split anergized Natural Killer cells halt inflammation by inducing stem cell differentiation, resistance to NK cell cytotoxicity and prevention of cytokine and chemokine secretion. Oncotarget, 6(11), 8947-8959. 
  74. Park S, Kanayama K, Kaur K, Tseng HC, Banankhah S, Quje DT, Sayre JW, Jewett A, Nishimura I. Osteonecrosis of the Jaw Developed in Mice: DISEASE VARIANTS REGULATED BY γδ T CELLS IN ORAL MUCOSAL BARRIER IMMUNITY. J Biol Chem. 2015 Jul 10;290(28):17349-66. doi: 10.1074/jbc.M115.652305. Epub 2015 May 26.PMID:26013832
  75. Halder RC, Almasi A, Sagong B, Leung J, Jewett A, Fiala M. Curcuminoids and ω-3 fatty acids with anti-oxidants potentiate cytotoxicity of natural killer cells against pancreatic ductal adenocarcinoma cells and inhibit interferon γ production. Front Physiol. 2015 May 22;6:129. doi: 10.3389/fphys.2015.00129. eCollection 2015. PMID: 26052286
  76. Tseng HC, Arasteh A, Kaur K, Kozlowska A, Topchyan P, Jewett A. Differential Cytotoxicity but Augmented IFN-γ Secretion by NK Cells after Interaction with Monocytes from Humans, and Those from Wild Type and Myeloid-Specific COX-2 Knockout Mice. Front Immunol. 2015 Jun 9;6:259. doi: 10.3389/fimmu.2015.00259. eCollection 2015. PMID: 26106386
  77. Magister, S., Tseng, H., Bui, V., Kos, J., & Jewett, A. (2015). Regulation of split anergy in natural killer cells by inhibition of cathepsins C and H and cystatin F. Oncotarget, 5. 2015 Sep 8;6(26):22310-27
  78. Han-Ching Tseng1&; Keiichi Kanayama2,3&; Kawaljit Kaur1&; So-Hyun Park1, Sil Park1,2; Anna Kozlowska4; Shuting Sun5, Charles E. McKenna5, Ichiro Nishimura**1,2 and Anahid Jewett*1.Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo; Role in osteoclast-mediated NK cell activation. Oncotarget, 2015 Aug 21;6(24):20002-25
  79. Han-Ching Tseng, Akihito Inagaki, Vickie T. Bui, Nicholas Cacalano, Noriyuki Kasahara, Yan-gao Man and Anahid JewettDifferential Targeting of Stem Cells and Differentiated Glioblastomas by NK Cells,                Journal of Cancer, 2015; 6(9): 866-876. doi: 10.7150/jca.11527
  80. Bui, V. T., H.-C. Tseng, P. O. Maung, A. Kozlowska, K. Mann, P. Topchyan and A. Jewett. “Augmented IFN-γ and TNF-α Induced by Probiotic Bacteria in NK Cells Mediate Differentiation of Stem-Like Tumors Leading to Inhibition of Tumor Growth and Reduction in Inflammatory Cytokine Release; Regulation by IL-10.” Frontiers in Immunology, 6:576.doi: 10.3389/fimmu. 2015.00576
  81. Rezzadeh KS, Hokugo A, Jewett A, Kozlowska A, Segovia LA, Zuk P, Jarrahy R. Natural Killer Cells Differentiate Human Adipose-Derived Stem Cells and Modulate Their Adipogenic Potential. 
  82. Plast Reconstr Surg. 2015 Sep;136(3):503-10. doi: 10.1097/PRS.0000000000001536. PMID: 26313823
  83. Marcela Romero Reyes and Anahid Jewett, Increased activation and survival of immune effectors during anti-TNF-α therapy: Lessons learned from TNF-/- mice; New Approaches combating Cancer & Aging 2015; 2: 76-88
  84. Latham J, Fong H, Jewett A, Johnson JD, Paranjpe A. Disinfection Efficacy of Current Regenerative Endodontic Protocols in Simulated Necrotic Immature Permanent Teeth. J Endod. 2016 Jun 29. pii: S0099-2399(16)30248-5. doi: 10.1016/j.joen.2016.05.004. [Epub ahead of print], PMID: 27372159
  85. Anna K. Kozlowska, Han-Ching Tseng, Kawaljit Kaur, Paytsar Topchyan, Akihito Inagaki, Vickie T. Bui, Noriyuki Kasahara, Nicholas Cacalano and Anahid Jewett Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells; Cancer Immunology and Immunotherapy; 2016 Sep;65(9):1085-97. doi: 10.1007/s00262-016-1866-x. Epub 2016 Jul 20.
  86. Yujie Sun, Kawaljit Kaur, Keiichi Kanayama, Kenzo Morinaga, Sil Park, Akishige, Hokugo, Anna Kozlowska, William H. McBride, Jun Li, Anahid Jewett, Ichiro Nishimura.  Plasticity of Myeloid Cells during Oral Barrier Wound Healing and the Development of Bisphosphonate-Related Osteonecrosis of the Jaw. J Biol Chem. 2016 Aug 11. pii: jbc.M116.735795. [Epub ahead of print
  87. Kaur K, Cook J, Park S, Topchyan P, Kozlowska A, Ohanian N, Fang C, Nishimura I and Jewett A (2017). Novel strategy to expand super-charged NK cells with significant potential to lyse and differentiate cancer stem cells; Differences in NK expansion and function between healthy and cancer patients. Front. Immunol 7:9. doi: 10.3389/fonc.2017.00009
  88. Anna Kozlowska, Paytsar Topchyan, Kawaljit Kaur, Han-Ching Tseng, Antonia Teruel, Toru Hiraga, and Anahid Jewett, Differentiation by NK cells is a prerequisite for effective targeting of cancer stem cells/poorly differentiated tumors by chemopreventive and chemotherapeutic drugs; Journal of Cancer, 2017; 8(4): 537-554. doi: 10.7150/jca.15989
  89. Milica M Perisic Nanut, Jerics Sabotič, Urban Svajger, Anahid Jewett, Janko Kos; Cystatin F affects natural killer cell cytotoxicity, ” Frontiers in Immunology” 2017 Nov 13;8:1459. doi: 10.3389/fimmu.2017.01459. eCollection 2017.
  90.  Kawaljit Kaur1, Hui-Hua Chang1, Jessica Cook1, Guido Eibl1, Anahid Jewett; Super-charged NK cells prevent inhibition of IFN-g secretion by gingival immune cells in pancreatic and oral tumor-bearing BLT-humanized mice; distinct modulation at the pre-cancerous and cancerous stages ” Frontiers in Immunology” 2017 Dec 4;8:1606. doi: 10.3389/fimmu.2017.01606. eCollection 2017.
  91. Kawaljit Kaur1, Hui-Hua Chang2, Paytsar Topchyan1, Jessica Morgan Cook1, Andre Barkhordarian1, Guido Eibl2 and Anahid Jewett1,3,4*Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice, Front Immunol. 2018; 9: 1229.
  92. Kaur, K., P. Topchyan, A. K. Kozlowska, N. Ohanian, J. Chiang, P. O. Maung, S.-H. Park, M.-W. Ko, C. Fang, I. Nishimura and A. Jewett (2018). “Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated oral tumors in vivo in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs.” OncoImmunology: 2018 Feb 22;7(5):e1426518. doi: 10.1080/2162402X.2018.1426518. eCollection 2018

Proceedings & Reviews

  1. Jewett, A., Cavalcanti, M., and Bonavida, B.  Expression of CD16 and KIR in NK cells signaled for apoptosis.  Leukocyte Typing VI: Proceedings of the 6th International Workshop/Conference, Japan, 1997, p 298-300.
  2. Jewett, A., Cavalcanti, M., and Bonavida, B.1.  Pivotal role of endogenously synthesized TNF-α by NK cells in regulating  target cell and anti-CD16 mAb mediated apoptosis in NK cells.  Leukocyte Typing VI: Proceedings of the 6th International Workshop/Conference, Japan, 1997,824-826.
  3. Anahid Jewett, Nicholas A. Cacalano. Emerging mechanisms of immunosuppression in oral cancers. Critical Reviews in Oral Biology and Medicine, J. Dent. R, 85 (12):1061-1073,2006 .
  4. Jewett, A. and H.C. Tseng, Tumor induced inactivation of natural killer cell cytotoxic function; implication in growth, expansion and differentiation of cancer stem cells. J Cancer. 2011;2:443-57. Epub 2011 Aug 10.
  5. Anahid Jewett, Han-Ching Tseng, Aida Arasteh, Saba Saadat, Russell E. Christensen and Nicholas A. Cacalano. Natural Killer cells preferentially target cancer stem cells; Role of monocytes in protection against NK cell mediated lysis of cancer stem cells. Curr Drug Deliv.,2011, Oct 21. [Epub ahead of print]
  6. Jewett, A. and H.C. Tseng, Potential rescue, survival and differentiation of cancer stem cells and primary non-transformed stem cells by monocyte-induced split anergy in natural killer cells. Cancer Immunol Immunother. 2012 Feb;61(2):265-74. Epub 2011 Nov 25.
  7. Shurin MR, Umansky V, Malyguine A, Hurwitz AA, Apte RN, Whiteside T, Jewett A, Thanavala Y, Murphy WJ.  Cellular and molecular pathways in the tumor immunoenvironment: 3rd Cancer Immunotherapy and Immunomonitoring (CITIM) meeting, 22-25 April 2013, Krakow, Poland. Cancer Immunol Immunother. 2014 Jan;63(1):73-80. doi: 10.1007/s00262-013-1501-z. Epub 2013 Nov 24. PMID:24271210
  8. Jewett A, Man YG, Cacalano N, Kos J, Tseng HC. Natural killer cells as effectors of selection and differentiation of stem cells: Role in resolution of inflammation. [Published online ahead of print February 27, 2014] J Immunotoxicol doi: 103109/1547691X2013877104.
  1. Natalia Aptsiauri, Anahid Jewett, Arthur A. Hurwitz, Michael R. Shurin, Viktor Umansky.  Redefining cancer immunotherapy – optimization, personalization and new predictive biomarkers: 4th Cancer Immunotherapy and Immunomonitoring (CITIM) meeting, 27–30 April 2015, Ljubljana, Slovenia, Cancer Immunology and Immunotherapy, 2016 Jul;65(7):835-45. doi: 10.1007/s00262-016-1822-9. Epub 2016 Mar 31. Review.
  2. Kozlowska AK, Kaur K, Topchyan P, Jewett A, Adoptive transfer of osteoclast-expanded natural killer cells for immunotherapy targeting cancer stem-like cells in humanized mice. Cancer Immunol Immunother. 2016 Jul;65(7):835-45. doi: 10.1007/s00262-016-1822-9. Epub 2016 Mar 31. Review
  1. Anna K. Kozlowska, Kawaljit Kaur , Paytsar Topchyan, Anahid Jewett, Novel strategies to target cancer stem cells by NK cells; studies in humanized mice; Frontiers of Bioscience; (Landmark edition), 2017; 22: 370-384.
  2. Kawaljit Kaur1, Milica Perišić Nanut2, Mengwei Ko1, Tahmineh Safaie1, Janko Kos2,3 and Anahid Jewett1,4* Natural Killer cells target and differentiate cancer stem-like cells/undifferentiated tumors; strategies to optimize their growth and expansion for effective cancer immunotherapy; Current Opinion in Immunology; “In press”
  3.  Jewett A. Editorial overview: Tumour immunology: Are we on the path to win the battle against cancer through immunotherapy? Curr Opin Immunol. 2018 Apr;51:vii-ix. doi: 10.1016/j.coi.2018.04.018.
  4. Kawaljit Kaur1, Milica Perišić Nanut2, Mengwei Ko1, Tahmineh Safaie1, Janko Kos2,3 and Anahid Jewett1,4* Natural killer cells target and differentiate cancer stem-like cells/undifferentiated tumors: strategies to optimize their growth and expansion for effective cancer immunotherapy.; Curr Opin Immunol. 2018 Apr;51:170-180. doi: 10.1016/j.coi.2018.03.022. Epub 2018 Apr 10.
  5. Janko Kos1,2 · Milica Perišić Nanut1 · Mateja Prunk1 · Jerica Sabotič1 · Esmeralda Dautović3 · Anahid Jewett4. Cystatin F as a regulator of immune cell cytotoxicity; Cancer Immunology and Immunotherapy; https://doi.org/10.1007/s00262-018-2165-5
  6. Anahid Jewett1,2*, Janko Kos3,4, Yuman Fong5,6, Meng-Wei Ko1, Tahmineh Safaei1, Andre Barkhordarian1, Milica Perišić Nanut3, Kawaljit Kaur1 , NK cells shape pancreatic and oral tumor microenvironments; role in inhibition of tumor growth and metastasis. Seminars in Cancer Biology, “In press”

Book Chapters

  1. Bonavida, B., Jewett, A., and Mencia-Huerta, J.M.  Biology of Platelet Activating Factor (PAF) Interaction with Human Peripheral Blood Monocytes and induction of Tumor Necrosis Factor (TNF) Secretion. In   “The Ginkgolides Vol 2”, Chemistry, Biology, Pharmacology and Clinical Perspectives, P. Braquet, ed., J. R. Proc. science Publishers, 2:685-696, 1989.
  2. Lebow, L.T., Gan, X.-H., Jewett, A., and Bonavida, B. Induction and secretion of TNF- during the maturation and differentiation of human natural killer cells.  In “Tumor necrosis factor:  Structure function relationship and clinical application,” T. Osawa and B. Bonavida, eds., Karger Press, Basel, pp. 144-151, 1992.
  3. Bonavida, B. and Jewett, A.  Maturation, differentiation, and inactivation of human peripheral blood NK cells.  In “L’Immuno-Intervention”, S. Chouaib and J.M. Mencia-Huerta, eds., Media Science, pp. 181-188, 1994.
  4. Bonavida, B. and Jewett, A.  Natural killer cells in HIV infection. Chapter 17, Immunology of HIV infections,  S. Gupta, ed. Plenum  Press, New York, 353-364, 1996.
  5. JOHN A. YAGIELA AND ANAHID JEWETT, Pharmacology and Therepeutics for Dentistry, Immunotherapy, Chapter 41., 2010
  6. Anahid Jewett and Han-Ching Tseng, Tumor microenvironment may shape the function and phenotype of NK cells through the induction of split anergy and generation of regulatory NK cells. Chapter 15 “The Tumor microenvironment” Edited by Drs. Michael R. Shurin, Viktor Umansky and Anatoli Malyguine, 2013
  7. ANAHID JEWETT and Han-Ching Tseng, Pharmacology and Therepeutics for Dentistry, 7e, Immunotherapy, Chapter 35, 2015
  8. Anahid Jewett 1,2* Janko Kos3,4 , Mengwei Ko1, Tahmineh Safaei1, Omid Nikjah1, Majed Bamatraf1, Paul Wong1, Artin Keshishian Namagerdi1, and Kawaljit Kaur 1 Natural killer cells pave the road for effective targeting of cancer; inhibition of their effector function at the pre-neoplastic and neoplastic stages of tumorigenesis;  Translational Research: Recent Progress and Future Directions; Book chapter, “In press” 

Submitted Manuscripts

  1. Kawaljit Kaur1, Nick Ohanian, Jessica Cook1, Paytsar Topchyan1, Anna Kozlowska1,2,  Changge Fang3, Ichiro Nishimura4,5, and Anahid Jewett1,4,6,Osteoclast activated super-charged NK cells preferentially and rapidly expand CD8+ T cells resulting in a faster decline in NK cell numbers from pancreatic cancer patients and BLT humanized mice 
  2. Kawaljit Kaur1, Nick Ohanian, Jessica Chiang, Jessica Cook, Phyu Ou Maung1, Anna Kozlowska1,4, Paytsar Topchyan1, Vicki T. Bui1, So-Hyun Park1, Nicholas Cacalano2,3 and Anahid Jewett1,2 ,Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated pancreatic tumors in vivo in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs 
  3. Anna Kozlowska, Paytsar Topchyan1, Nick Ohanian, Jessica Chiang, Jessica Cook, Anna Kozlowska1,4,  and Anahid Jewett1,2 ,Super-charged NK cells in combination with tumor vaccine inhibit growth and progression of Melanoma tumors in vivo in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs.
  4. Diana Wong, Nick Ohanian, Eric Lee, Avina Paranjpe, Eric Sung and Anahid Jewett. N-acetyl cysteine prevents toxicity of bleaching agents without affecting their esthetic therapeutic effect. “Manuscript submitted”

Teaching

  1. Course Chair and instructor for OSD211 (systems 5) for pre-doctoral dental students
  2. Course instructor for the section of Immunology in Foundations for pre-doctoral dental students
  3. Course Chair and instructor for Fundamentals  of Immunology (OB 215) for Oral Biology graduate students and dental residents.
  4. Course instructor for Adaptive Immunity section (both didactic and discussion section) for M252 for UCLA PhD students
  5. Course instructor for M202 pre-seminar course for Oral Biology graduate students and dental residents (one lecture)
  6. Course Chair and instructor BIO MED 19 (Fiat Lux seminar) for undergraduate students
  7. Organizer of Faculty Seminar Series for the School of Dentistry
  8. Graduate student seminar. Prepare and lead graduate student seminar in the department of Pathology

Membership

  1. American  Association of Immunologist (AAI).
  2. American  Association of  Advancement for Science (AAAS).
  3. Chancellor’s Animal Research Committee (ARC)
  4. Dental Research Institute
  5. International and American Association of Dental Research (IADR, AADR)
  6. Jonsson Comprehensive Cancer Center (JCCC)
  7. Southern California American Society for Microbiology (SCASM).
  8. UCLA Tumor Immunology subgroup
  9. Wintraub Center for reconstructive surgery and bioengineering

Academic Committees

  1. SOD Strategic plan committee. 2017-2018
  2. Faculty Executive Committee (FEC). 2008-2011; 2016-present
  3. Appointments, Promotions and Appraisals committee (APA). 2008-2011 (chair) 
  4. Committee on Committees (ConC) (Chair) 2007-2011
  5. Oral Biology PhD Admissions Committees, 1997-present
  6. Oral Biology Master’s Admissions Committees, 1997-present
  7. Dental School Curriculum Committee, 1997-2010
  8. Research Advisory Committee (chair), 2002-2012
  9. Animal Research Committee, 2000-2011
  10. Animal Program Advisory Committee, 2015- present
  11. Oral Biology Curriculum Committee (chair), 2002-2007
  12. Access PhD program steering Committee, 2003-2005
  13. Council on Research, 2003-2006, 2009-present
  14. Charges committee, 2010-2012
  15. MILA 2011-2014
  16. Rules and Jurisdiction (Chair) 2011-2015
  17. Systemwide UC Rules and Jurisdiction (chair) 2013-2014
  18. Promotion and Tenure committee; 2014-2017
  19. UCLA Regents Scholarship committee; 2014-present 

Community Services

  1. American Association of Immunology- Teacher Training (H.S. Level)
  2. Francis Polytechnic HS, LAUSD – Science Project Judge

Editorial Activities

  1. Associate Editor,  Journal of frontiers in tumor immunity
  2. Editorial board of ISRN Immunology
  3. Editorial board of Journal of Cancer
  4. Editorial board of  Journal of Stem Cell & Regenerative Medicine                                                                                                                                                                             
  5. Journal of Clinical Immunology
  6. International Journal of Oral Biology
  7. Journal of Infection and Immunity
  8. Journal of Cellular Immunology 
  9. Journal of Leukocyte Biology
  10. Journal of Dental Research                                              
  11. Blood
  12. Journal of Pros (JPD)
  13. Journal of Immunology                                                                                                                                 
  14. American Journal of Pathology
  15. PLos journals                                                                                                                                                   
  16. eCells and Materials
  17. Journal of Cancer
  18. Journal of Stem Cell & Regenerative Medicine
  19. Cancer Immunology and Immunotherapy
  20. Journal of Cancer research
  21. Journal of clinical cancer research

Consulting Activities

  1. Consultant to Drew University
  2. Consultant to improve high school science curriculum
  3. Grant reviewer for United Kingdom, Netherlands,Qatar, Israel,;
  4. Guidpoint global

NIH Study Sections

  1. Immunology fellowship review study section 2009-2016
  2. Innate Immunity and inflammation, ad-hoc reviewer 2009-present 
  3. Innate Immunity and Inflammation, regular member 2003-2009 
  4. Transplantation, Tumor Immunology and Tolerance- ad-hoc reviewer 2003, 2004,2005,2011,2015,2016,2017
  5. Innate Immunity and Host Defense,  ad-hoc member served 2003

Grant reviewer

  1. Cancer Research UK
  2. U.S.-Israel Binational Science Foundation
  3. Amsterdam
  4. Qatar
  5. Swiss Cancer League
  6. Advancing a Healthier Wisconsin Endowment 

Patents

1-UCLA case No. 2005-379-4; USSN 12/976,820, METHODS TO PREVENT CYTOTOXICITY USING N-ACETYL-CYSTEINE 

2-UCLA Case No. 2007-347; USE OF NATURAL KILLER (NK) CELLS IN CANCER TREATMENT

3-UCLA CASE#:2017-400; Foley ref. UCH-107.60

4-UCLA UC-2017-183-1-LA] – Foley Hoag Ref. No. UCH-10560 (32246-10560)

Current Status of the IP

UCLA-048CIP; 14/637,235; Depletion of Cancer Stem Cells (strategy to expand super-charged NK cells); We have an agreement for the use of this technology in human clinical trials in China

  1. Case No. 2017-183-1-LA; ORAL COMPOSITIONS FOR REGULATING IMMUNE RESPONSES AND METHODS RELATED THERETO (AJ2 Adjuvant therapy to augment super-charged NK function in vivo); We have a letter of intent from D. M. Advantage, Inc; an affiliate of red chamber, for the exclusive use of this technology in USA. We also have an expressed interest by Slovenian biotech corridor.
  2. Case No. UCLA 2017-400-1; Compositions and Methods for Activating NK cells (Strategy to use super-charged NK cells to expand super-charged CD8+ T cells).
2005-379 INHIBITION OF DENTAL RESIN TOX 1/18/2005
2006-585  OSTEOCONDUCTIVE BONE CEMENT 4/20/2006
2007-347  STEM CELLS & OSTEOBLASTS 12/20/2006
2017-183  ADJUVANT THERAPY AJ2 9/2/2016
2017-400  OSTEOCLAST ACTIVATED NK CELLS 10/19/2016
2019-047  INABILITY OF MONOCYTES 8/14/2018
2019-245  IMMUNOTHERAPY OF CANCER 8/25/2018
2019-635  UNIQUE NK SPECIFIC TESTS 2/13/2019
2019-700  NK INACTIVATION IN CANCER 3/1/2019
2020-390  PATHOLOGY IN ALS & TREATMENT 10/12/2019
2019-700-2 CANNABIS LIMITS CANCER STEM CELL GROWTH IN POORLY DIFFERENTIATED CANCERS 12/17/2019

Summary of Research and Creative Activities

One of my first and major contributions to science and NK cell biology was the identification, characterization and the establishment of the concept of split anergy in NK cells. I coined this concept to demonstrate that during interaction of NK cells by tumor-targets or signaling through key receptors such as CD16 and NKp46, NK cells lose the ability to mediate cytotoxicity, and switch their phenotype to promote differentiation of other cells through either membrane bound or secreted forms of IFN-g and TNF-a. During these studies I also determined that functional inactivation of NK cells in cancer patients is quite dominant since the addition of a number of different cytokines or cross linking of the key receptors were unable to reverse the inactivation of NK cell function fully. The establishment of concept of split anergy was crucial for our future discoveries since the concept of selection and differentiation of cancer stem cells by NK cells was born out of this concept.  

The second important discovery which also formed the basis for the conception that NK cells were important for the selection and differentiation of cancer stem cells as well as healthy stem cells came from the discoveries that when genes of significance such as NFkB, TNF-a or COX2 were knocked out, NK cells became significantly activated, and they mediated increased cytotoxicity as well as cytokine secretion. Thus, we postulated that when cells were de-differentiated by knocking important genes, NK cells were signaled to become activated in order to aid in the differentiation of de-differentiated cells. In addition, we also determined that co-engagement of important receptors such as CD16 and CD94 or CD16 and MHC class I were able to substantially increase cytokine and chemokine secretion in the presence of severe decrease in cytotoxicity, demonstrating the higher the signals received through the ligands, the more severe the split anergy, and a shift in the ability of NK cells to provide differentiation of the cells 

In line with the significance of NK cells in providing differentiation signals we also identified N-acetylcysteine (NAC) as an important differentiation agent, which provided protection from certain drug induced cell death through the functions of NFkB and JNK. Indeed, we obtained US patent for the use of NAC in protection against bleaching agents. However, NAC synergizes with some chemotherapeutic drugs such as paclitaxol to induce increased cell death. Due to this discovery we now use this agent to provide differentiation of cancer stem cells, since we have identified that either NK or NAC differentiated cancer stem cells become highly susceptible to chemotherapeutic drugs.

One of my most significant contributions is the identification of NK cells as the key cells to target and kill cancer stem cells. I have identified that not only NK cells target cancer stem cells but also healthy non-transformed stem cells including embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), dental pulp stem cells (DPSCs) and induced pleuripotent stem cells (iPSCs). In addition, I have identified that differentiated cells are not targeted by the NK cells and that de-differentiation of the cells activates NK cell function to increase cytotoxicity as well as cytokine secretion in order to provide selection of cancer stem cells and subsequent differentiation of selected stem cells.

The most recent discoveries were built upon the concept of split anergy in NK cells. NK differentiated cancer stem cells as well as healthy stem cells when differentiated not only become resistant to NK cell mediated cytotoxicity, but also they lose the ability to induce cytokine secretion by the NK cells, therefore, we postulated that differentiation by NK cells are the means of halting inflammation, and more recently we have demonstrated the direct in vivo evidence of this observation in humanized BLT mouse model system in oral, pancreatic and melanoma tumor models. Differentiation of the cancer stem cells inhibits cell growth and metastasis in addition to inhibition of inflammation. NK cells differentiate stem cells via the dual functions of membrane bound or secreted IFN-g and TNF-a.  We also investigated the mechanisms by which split anergy is induced in NK cells and found that both Cathepsin C and H and Cystatin F functions are important for the induction of split anergy in NK cells. In addition, we have also found osteoclasts to have significant activating effect on NK cells and now are using this strategy to expand NK cells with superior ability to target cancer stem cells and provide differentiation for the selected cancer stem cells, which we coined as super-charged NK cells. One application of osteoclast expanded NK cells was able to prevent growth and metastasis of oral, pancreatic and melanoma tumors in humanized BLT mice. We are now planning in using osteocalst expanded NK cells, a patented technology, in human clinical trials.

Below you will find my collaborative work with other investigators at UCLA and elsewhere around the world.